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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
receptor trafficking
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "receptor trafficking" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: AZD0780; PCSK9-IN-12
Target:
Research Areas:
Laroprovstat (AZD0780) is an orall active PCSK9 inhibitor. PCSK9-IN-12 has bind affinity for PCSK9 with a Kd value of <200 nM. Laroprovstat binds to a pocket in the PCSK9 C-terminal domain and does not affect the PCSK9-LDL receptor (LDLR) interaction. Laroprovstat inhibits lysosomal trafficking of PSCK9-LDLR complexes and prevents PCSK9-induced LDLR degradation. Laroprovstat can be used for the research of hypercholesterolemia .
Cat. No.: HY-114457
CAS No.: 245126-95-8
Synonyms: L-alpha-Phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2
Category:
Human Gut Microbiota Metabolites Other Diseases Lipids Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-P5351A
Target:
Research Areas:
Cat. No.: HY-125836
CAS No.: 2206788-99-8
Target:
Research Areas:
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.
CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca 2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively .
Cat. No.: HY-P5351
Cat. No.: HY-165426
CAS No.: 3031522-14-9
Target:
Research Areas:
HB-230 is a Transglutaminase-2 (TG2) (human IC50 = 4.9 μM) inhibitor and a selective fluorescent imaging probe for active TG2 localization. HB-230 modifies TG2 Cys277 to sustain the enzyme open conformation. HB-230 forms a ternary complex with TG2 and α2-macroglobulin, undergoes receptor-mediated endocytosis, and trafficks directly to lysosomes without early/late endosome fusion. HB-230 exhibits TG2 activity-dependent and α2-macroglobulin-dependent uptake. HB-230 can be used for the research of celiac disease, (Ex/Em = 649/665 nm) .
Cat. No.: HY-P3340
CAS No.: 189224-35-9
Target:
Research Areas:
Cat. No.: HY-174744
Target:
Research Areas:
Human CCR4 mRNA encodes the human C-C motif chemokine receptor 4 (CCR4) protein, a member of G protein-coupled receptors family. CCR4 is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
Cat. No.: HY-P1057
CAS No.: 243843-43-8
Target:
Research Areas:
Cat. No.: HY-D2943
Synonyms: SNAP-SS-SulfoCy3
Cat. No.: HY-D2930
Synonyms: SNAP-SS-SulfoCy5
Cat. No.: HY-P992146
CAS No.: 3060218-90-5
Synonyms: MYTX-011 Antibody; Q-397
Target:
Research Areas:
Cat. No.: HY-P77240
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TMED1; P24 Family Protein Gamma-1; Transmembrane P24 trafficking Protein 1; MGC1270; IL1RL1LG; ST2L; P24gamma1; Tp24; Il1rl1l; Transmembrane Emp24 Domain Containing 1; P24g1; Interleukin 1 receptor-Like 1 Ligand; Transmembrane Emp24 Protein Transport Doma
Species:
Human
Source:
HEK293
Cat. No.: HY-P77241
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TMED1; P24 Family Protein Gamma-1; Transmembrane P24 trafficking Protein 1; MGC1270; IL1RL1LG; ST2L; P24gamma1; Tp24; Il1rl1l; Transmembrane Emp24 Domain Containing 1; P24g1; Interleukin 1 receptor-Like 1 Ligand; Transmembrane Emp24 Protein Transport Doma
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P72445
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TMED1; P24 Family Protein Gamma-1; Transmembrane P24 trafficking Protein 1; MGC1270; IL1RL1LG; ST2L; P24gamma1; Tp24; Il1rl1l; Transmembrane Emp24 Domain Containing 1; P24g1; Interleukin 1 receptor-Like 1 Ligand; Transmembrane Emp24 Protein Transport Doma
Species:
Human
Source:
HEK293
Cat. No.: HY-P992151
Synonyms: LT1002
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
