1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. CCR4 antagonist 2

CCR4 antagonist 2 

Cat. No.: HY-125836
Handling Instructions

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.

For research use only. We do not sell to patients.

CCR4 antagonist 2 Chemical Structure

CCR4 antagonist 2 Chemical Structure

CAS No. : 2206788-99-8

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Description

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].

IC50 & Target

IC50: 40 nM (Ca2+flux); 70 nM (CTX) (CCR4 antagonist 2)[1]

Molecular Weight

511.45

Formula

C₂₆H₂₈Cl₂N₆O

CAS No.

2206788-99-8

SMILES

ClC(C=C(Cl)C=C1)=C1[[email protected]@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[[email protected]](N5[[email protected]](CO)CCC5)[[email protected]](C)C4)C=N3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CCR4 antagonist 2
Cat. No.:
HY-125836
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