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49

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4

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Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119976
    Boscalid
    1 Publications Verification

    Environmental Pollutants Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase Infection
    Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .
    Boscalid
  • HY-N9497

    Galectin Fungal Infection
    Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .
    Galactinol
  • HY-14778

    GSK 221149; GSK 221149A

    Oxytocin Receptor Neurological Disease Endocrinology
    Retosiban (GSK221149A) is a potent, selective, and orally active oxytocin receptor antagonist (Ki (hOT) = 0.65 nM, Ki (rOT) = 4.1 nM) with no detectable agonist activity. Retosiban has nanomolar affinity for the oxytocin receptor with >1400-fold selectivity over the closely related vasopressin receptors. Retosiban inhibits spontaneous and induces uterine contractions. Retosiban can be studied in research for preterm labour .
    Retosiban
  • HY-139161

    Environmental Pollutants Fungal Infection
    Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases .
    Penflufen
  • HY-121935

    Environmental Pollutants Fungal Infection
    Tecnazene is a dinitroaromatic fungicide and plant growth regulator. Tecnazene binds irreversibly to human skin tissues and exhibits acute toxicity in Rattus norvegicus (brown rat). Tecnazene exerts sprouting-inhibiting and antifungal activities by inhibiting the sprouting of potato tuber buds and blocking the growth and reproduction of fungi that cause dry rot. Tecnazene has significant antifungal and sprouting-inhibiting activities, and shows high toxicity to aquatic organisms such as freshwater fish and crustaceans. Tecnazene is used for sprouting inhibition and dry rot control during potato storage .
    Tecnazene
  • HY-W015343

    m-Methoxyphenylacetic acid

    Endogenous Metabolite Others
    3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot .
    3-Methoxyphenylacetic acid
  • HY-Y1313

    m-Carboxynitrobenzene; m-Nitrobenzenecarboxylic acid; m-Nitrobenzoic acid

    Bacterial Fungal Infection
    3-Nitrobenzoic acid (m-Carboxynitrobenzene; m-Nitrobenzenecarboxylic acid; m-Nitrobenzoic acid) is an antioxidant and antibacterial agent that can kill bacteria and fungi. 3-Nitrobenzoic acid can be degraded or reduced by certain bacteria (such as Pseudomonas) and fungi (such as white rot fungi) into aldehydes and alcohols .
    3-Nitrobenzoic acid
  • HY-17518

    IR5885; Valiphenal

    Environmental Pollutants Bacterial Fungal Infection
    Valifenalate (IR5885; Valiphenal) is an insecticide agent and fungicide, which is approved for application on high-value crops such as grapes, tomatoes and other vegetables. Valifenalate interferes with cell-wall synthesisValifenalate is effective against various types of mildew. Valifenalate can be used against crown rot of rose cuased by Phytophthora citrophthora. Valifenalate induces non-adverse thyroid changes via adaptive induction of uridine 5’-diphosphoglucuronosyltransferase (UGT) in the liver of dogs and rats .
    Valifenalate
  • HY-117451

    Bacterial Infection
    Dodine is a fungicide with plant disease suppressive activity. Dodine is used to control black spot on apples, pears and pecans, brown rot on peaches, and a variety of foliar diseases of peaches, strawberries, cherries, jacaranda and black walnuts. Dodine is also used as an industrial biocide and preservative .
    Dodine
  • HY-N10346A

    3-Butenyl glucosinolate

    Lipase Bacterial Infection Cancer
    Gluconapin (3-Butenyl glucosinolate) is an orally active aliphatic glucosinolate and also a flavor modifier. Gluconapin inhibits the elevation of plasma triglyceride levels in mice. Gluconapin also exhibits certain antibacterial activity .
    Gluconapin
  • HY-135258

    Galectin Fungal Others
    Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .
    Galactinol dihydrate
  • HY-W112021

    2,5-Dimethoxybenzoquinone

    Biochemical Assay Reagents Others
    2,5-DMBQ (2,5-Dimethoxybenzoquinone) serves as an extracellular reductant. 2,5-DMBQ is involved in a crucial redox cycle, namely the extracellular hydroquinone-quinone redox cycle. In this cycle, 2,5-DMBQ is capable of reducing extracellular Fe ³⁺ and generating H2O2. 2,5-DMBQ plays a pivotal role in the biodegradation mechanism of brown rot fungal, assisting the fungi in decomposing and utilizing organic matter .
    2,5-DMBQ
  • HY-121935R

    Reference Standards Fungal Infection
    Tecnazene (Standard) is the analytical standard of Tecnazene. This product is intended for research and analytical applications. Tecnazene is a dinitroaromatic fungicide and plant growth regulator. Tecnazene binds irreversibly to human skin tissues and exhibits acute toxicity in Rattus norvegicus (brown rat). Tecnazene exerts sprouting-inhibiting and antifungal activities by inhibiting the sprouting of potato tuber buds and blocking the growth and reproduction of fungi that cause dry rot. Tecnazene has significant antifungal and sprouting-inhibiting activities, and shows high toxicity to aquatic organisms such as freshwater fish and crustaceans. Tecnazene is used for sprouting inhibition and dry rot control during potato storage .
    Tecnazene (Standard)
  • HY-W087943

    Environmental Pollutants Fungal Infection
    Methyl octanoate is an ester volatile compound with an odor activity value greater than 1. Methyl octanoate helps impart brandy-like and fruity characteristics to persimmon wine. Methyl octanoate has a strong odor of citrus holly, camphor and menthol. Methyl octanoate can serve as an early marker for grape infection by *Coniella vitis*. Methyl octanoate can be used in studies related to grape white rot .
    Methyl octanoate
  • HY-W134163

    trans-2-Octenal

    Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Phosphatase Pyruvate Kinase Infection
    (E)-2-Octenal is an Antifungal agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot .
    (E)-2-Octenal
  • HY-N12982

    Others Others
    α-Calacorene is a sesquiterpene that can be isolated from Réunion vetiver oil .
    α-Calacorene
  • HY-W414596

    Fungal Infection
    Metconazole is a 14α-demethylation inhibitor (DMI) fungicide. Metconazole inhibits fungal ergosterol biosynthesis, inhibits mycelial growth and conidial germ tube elongation. Metconazole reduces antioxidant enzyme activities. Metconazole reduces occurrence of Fusarium crown rot in wheat .
    Metconazole
  • HY-171796

    Fungal Infection
    Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections) .
    Bromomonilicin
  • HY-N15600

    (-)-Merulidial

    Antibiotic Fungal Bacterial DNA/RNA Synthesis Infection Cancer
    Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .
    Merulidial
  • HY-N9378

    Fungal Infection
    3-Oxobetulin, an antifungal agent, shows antifungal activities against white rot fungus L. betulina and the brown rot fungus L. sulphureus .
    3-Oxobetulin
  • HY-161856

    mTOR Fungal Others
    Antifungal agent 106 (Compound Z31) is a benzoic acid derivative and a potential fungicide against Monilinia fructicola. Antifungal agent 106 exhibits antifungal activity with an EC50 value of 11.8 mg/L. It affects hyphal growth by disrupting cell membrane integrity, leading to increased membrane permeability and release of intracellular electrolytes. Antifungal agent 106 can be used in research related to brown rot of stone fruits .
    Antifungal agent 106
  • HY-W112021R

    2,5-Dimethoxybenzoquinone (Standard)

    Biochemical Assay Reagents Reference Standards Others
    2,5-DMBQ (2,5-Dimethoxybenzoquinone) serves as an extracellular reductant. 2,5-DMBQ is involved in a crucial redox cycle, namely the extracellular hydroquinone-quinone redox cycle. In this cycle, 2,5-DMBQ is capable of reducing extracellular Fe³⁺ and generating H2O2. 2,5-DMBQ plays a pivotal role in the biodegradation mechanism of brown rot fungal, assisting the fungi in decomposing and utilizing organic matter .
    2,5-DMBQ (Standard)
  • HY-164128

    Bacterial Infection
    AHL modulator-1 is a N-acylated L-homoserine lactone (AHL) modulator that modulating bacteria quorum sensing (QS). AHL modulator-1 can be used for the research of plant soft rot .
    AHL modulator-1
  • HY-139161R

    Fungal Reference Standards Infection
    Penflufen (Standard) is the analytical standard of Penflufen. This product is intended for research and analytical applications. Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases .
    Penflufen (Standard)
  • HY-W746764

    Endogenous Metabolite Fungal Infection
    E-α-Bisabolene is a non-cyclic sesquiterpene. E-α-Bisabolene holds a central position in the metabolic network of Phanerochaete chrysosporium. E-α-Bisabolene can be utilized by white-rot fungi for the biosynthesis of secondary metabolites .
    E-α-Bisabolene
  • HY-N14548

    Antibiotic Bacterial Infection
    Cryptosporiopsin can be isolated from the strain of Cryptosporiopsis sp. and Sporormia affinis. Cryptosporiopsin has antibacterial activity to many kinds of basidiomycetes, algal fungi, ascomycetes and hemiplegia fungi that cause wood rot, and can inhibit spore germination of Phytophthora potatoes. Cryptosporiopsin also has certain activity against gram-positive bacteria and negative bacteria .
    Cryptosporiopsin
  • HY-Y1313S

    m-Carboxynitrobenzene-d4; m-Nitrobenzenecarboxylic acid-d4; m-Nitrobenzoic acid-d4

    Isotope-Labeled Compounds Bacterial Fungal Infection
    3-Nitrobenzoic acid-d4 (m-Carboxynitrobenzene-d4; m-Nitrobenzenecarboxylic acid-d4; m-Nitrobenzoic acid-d4) is the deuterium labeled 3-Nitrobenzoic acid (HY-Y1313). 3-Nitrobenzoic acid is an antioxidant and antibacterial agent that can kill bacteria and fungi. 3-Nitrobenzoic acid can be degraded or reduced by certain bacteria (such as Pseudomonas) and fungi (such as white rot fungi) into aldehydes and alcohols.
    3-Nitrobenzoic acid-d4
  • HY-17518R

    IR5885 (Standard); Valiphenal (Standard)

    Reference Standards Bacterial Fungal Infection
    Valifenalate (Standard) is the analytical standard of Valifenalate. This product is intended for research and analytical applications. Valifenalate (IR5885; Valiphenal) is an insecticide agent and fungicide, which is approved for application on high-value crops such as grapes, tomatoes and other vegetables. Valifenalate interferes with cell-wall synthesisValifenalate is effective against various types of mildew. Valifenalate can be used against crown rot of rose cuased by Phytophthora citrophthora. Valifenalate induces non-adverse thyroid changes via adaptive induction of uridine 5’-diphosphoglucuronosyltransferase (UGT) in the liver of dogs and rats .
    Valifenalate (Standard)
  • HY-178050

    Fungal Succinate Dehydrogenase Infection
    SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research .
    SDH-IN-30
  • HY-119976S

    Isotope-Labeled Compounds Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase Others
    Boscalid-d4 is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .
    Boscalid-d4
  • HY-N12669

    Bacterial Reactive Oxygen Species (ROS) Apoptosis JNK Caspase Neurological Disease
    Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.
    Curcumin monoglucoside
  • HY-119976R

    Reference Standards Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase Infection
    Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .
    Boscalid (Standard)
  • HY-P2890I

    Biochemical Assay Reagents Metabolic Disease
    Laccase, White rot fungi (EC 1.10.3.2) is a blue copper oxidase that reduces molecular oxygen to water. Laccase oxidizes polyphenols, methoxy-substituted phenols and diamines, but not tyrosine. Oxidation by laccase is an one-electron reaction that generates a free radical.
    Laccase, White rot fungi
  • HY-P11783

    Fungal Infection
    Surfactin C2 is a lipopeptide produced by Bacillus subtilis A18 with antifungal activity. Surfactin C2 acts against Heterobasidion annosum and Heterobasidion parviporum. Surfactin C2 exerts its activity mainly through membrane‑active effects to disrupt fungal cell structures and inhibit mycelial growth. Surfactin C2 can be used for the research of butt rot and root rot of conifers .
    Surfactin C2
  • HY-W748786

    Fungal Infection
    Fenpyrazamine is an antifungal agent. Fenpyrazamine possesses antifungal, preventative, systemic, and lesion-inhibiting activities, as well as a long-lasting effect. Fenpyrazamine targets 3-keto reductase in the ergosterol biosynthesis pathway. Fenpyrazamine is effective against gray mold, stem rot, and brown rot .
    Fenpyrazamine
  • HY-W015343R

    m-Methoxyphenylacetic acid (Standard)

    Endogenous Metabolite Reference Standards Others
    3-Methoxyphenylacetic acid (Standard) is the analytical standard of 3-Methoxyphenylacetic acid. This product is intended for research and analytical applications. 3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot[1].
    3-Methoxyphenylacetic acid (Standard)
  • HY-121443

    Fungal Infection
    Cyflufenamid is an oxime amide fungicide. Cyflufenamid inhibits the formation of haustoria, colonies and spores of Blumeria graminis f. sp. tritici, and prevents germ tube elongation of Monilinia fructicola. Cyflufenamid is applicable to research related to powdery mildew and brown rot .
    Cyflufenamid
  • HY-E70119A

    Biochemical Assay Reagents Metabolic Disease
    Pectate Lyase, Clostridium acetobutylicum (EC 4.2.2.2) is an enzyme involved in the maceration and soft rotting of plant tissue. Pectate lyase is responsible for the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-reducing ends.
    Pectate Lyase, Clostridium acetobutylicum
  • HY-E70119D

    Biochemical Assay Reagents Metabolic Disease
    Pectate Lyase, Aspergillus sp. (EC 4.2.2.2) is an enzyme involved in the maceration and soft rotting of plant tissue. Pectate lyase is responsible for the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-reducing ends.
    Pectate Lyase, Aspergillus sp.
  • HY-E70119C

    Biochemical Assay Reagents Metabolic Disease
    Pectate Lyase, Caulobacter crescentus (EC 4.2.2.2) is an enzyme involved in the maceration and soft rotting of plant tissue. Pectate lyase is responsible for the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-reducing ends.
    Pectate Lyase, Caulobacter crescentus
  • HY-E70119B

    Biochemical Assay Reagents Metabolic Disease
    Pectate Lyase, Cellvibrio japonicus (EC 4.2.2.2) is an enzyme involved in the maceration and soft rotting of plant tissue. Pectate lyase is responsible for the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-reducing ends.
    Pectate Lyase, Cellvibrio japonicus
  • HY-122480

    SYP-1620

    Fungal ATP Synthase Cytochrome P450 Infection
    Fenaminstrobin (SYP-1620) is a strobilurin Fungicide. Fenaminstrobin binds to cytochrome bc1 in the mitochondrial respiratory chain, thereby inhibiting ATP production. Fenaminstrobin exhibits acute toxicity to Daphnia magna. Fenaminstrobin effectively controls diseases such as Fusarium ear rot, downy mildew, rice blast and pear scab .
    Fenaminstrobin
  • HY-N13282

    Bacterial Fungal Infection
    Glyceocarpin is a phytoalexin and antibacterial agent naturally occurring in Glycine max, with weak antifungal activity. Glyceocarpin serves as the biosynthetic precursor of Glyceollins II (HY-N18032) and Glyceollins III. Glyceocarpin can be biosynthesized by the prenyltransferase and subsequent modification by cytochrome P450 enzymes. Glyceocarpin can be used for the study of soybean root and stem rot caused by Phytophthora sojae .
    Glyceocarpin
  • HY-N16462

    Bacterial Infection
    2-(2-Heptenyl)-3-methyl-4(1H)-quinolone is a quinoline alkaloid found in Burkholderia sp. VY81. 2-(2-Heptenyl)-3-methyl-4(1H)-quinolone is promising for research of bacterial diseases in rice (e.g., soft rot) and other plant pathogens (e.g., Pythium ultimum, Fusarium oxysporum) .
    2-(2-Heptenyl)-3-methyl-4(1H)-quinolone
  • HY-N15141

    Insecticide Fungal Infection Cancer
    γ-Thujaplicin is a Hinokitiol (HY-B2230)-related compound that can be isolated from the wood of Thujopsis dolabrata. γ-Thujaplicin shows strong cytotoxic activities against human stomach cancer cell lines KATO-III and Ehrlich’s ascites carcinoma. γ-Thujaplicin exhibits potent and broad-spectrum antifungal activity on wood-rotting fungi, and insecticidal activity on the noxious insects. γ-Thujaplicin can be used for cancer and infection research and pest management .
    γ-Thujaplicin
  • HY-W281071

    Fungal Infection
    Antifungal agent 150 is an antifungal agent with activity against phytopathogenic fungi and in planta lesion suppression. Antifungal agent 150 inhibits ergosterol biosynthesis via targeted enzyme interaction. Antifungal agent 150 can be used for the research of plant diseases caused by Rhizoctonia solani, including banded leaf and sheath blight of maize .
    Antifungal agent 150
  • HY-N19791

    NF-κB Fungal Interleukin Related Infection Cancer
    6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 +/CD24 breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .
    6-Methoxymellein
  • HY-138439

    Mitochondrial Metabolism Infection
    Mandestrobin is a mitochondrial respiratory chain complex III inhibitor with bactericidal activity. The enantiomers of Mandestrobin exhibit differential bactericidal activity, with the R-enantiomer showing higher activity than the S-enantiomer .
    Mandestrobin
  • HY-W714852

    Insecticide Sodium Channel Infection
    Zeta-Cypermethrin is a type II pyrethroid insecticide. Zeta-Cypermethrin primarily acts on voltage-gated sodium channels in nerve cells, causing delayed channel closure, persistent nerve excitation and convulsions. In Drosophila, Zeta-Cypermethrin rapidly induces extremely high metabolic resistance that can be screened, and exhibits in vitro genotoxicity to human peripheral blood lymphocytes .
    Zeta-Cypermethrin

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