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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
stress-activated
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "stress-activated" in MCE Product Catalog:
4
Category:
4
4 Cited Publications
Cat. No.: HY-P80728
Synonyms: AI849689 antibody;
c Jun N terminal kinase 1 antibody;
C-JUN kinase 1 antibody;
c-Jun N-terminal kinase 1 antibody;
EC 2.7.11.24 antibody;
JNK 1 antibody;
JNK antibody;
JNK-46 antibody;
JNK1A2 antibody;
JNK21B1/2 antibody;
MAP kinase 8 antibody;
MAPK 8 antibody;
mapk8 antibody;
Mitogen activated protein kinase 8 antibody;
MK08_HUMAN antibody;
p54 gamma antibody;
Prkm8 antibody;
Protein kinase JNK1 antibody;
Protein kinase, mitogen-activated, 8 antibody;
SAPK 1 antibody;
SAPK gamma antibody;
SAPK1 antibody;
stress-activated protein kinase 1 antibody
2
2 Cited Publications
Target:
Research Areas:
SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research .
2
2 Cited Publications
Cat. No.: HY-P80996
Synonyms: CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A, MAPK14, Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, stress-activated protein kinase 2a, CSAID-binding protein, MAP kinase p38 alpha, SAPK2a
1
1 Cited Publications
Cat. No.: HY-W011109
CAS No.: 1177141-67-1
Target:
Research Areas:
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases .
1
1 Cited Publications
Cat. No.: HY-133028
CAS No.: 120615-25-0
Target:
Research Areas:
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases .
1
1 Cited Publications
Cat. No.: HY-P73848
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; stress-activated Protein Kinase JNK1; SAPK1; stress-activated Protein Kinase JNK; JNK1; stress-activated Protein Kinase 1; JNK; JNK21B1/2; stress-activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P80776A
Synonyms: p38 (phospho T180 + Y182); p-p38 (phospho T180 + Y182); p38 (phospho T180/Y182); CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP 1; CSBP 2; CSBP; CSBP1; CSBP2; CSPB 1; CSPB1; Cytokine suppressive anti inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX interacting protein 2; MAX-interacting protein 2; Mitogen activated Protein Kinase 14; Mitogen activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MK14_HUMAN; Mxi 2; Mxi2; p38 ALPHA; p38; p38 MAP kinase; p38 MAPK; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK 2A; SAPK2A; stress activated Protein Kinase 2A.
Research Areas:
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 induces apoptosis. HKB99 inhibits the formation of invasive pseudopodia and inhibits migration. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC) .
Target:
Research Areas:
DpC is a selective, orally active iron chelator with anticancer activity. DpC acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates caspase 3/9 to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .
Cat. No.: HY-114038
CAS No.: 607372-46-3
Target:
Research Areas:
SB-747651A is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A can be used for inflammation research .
Cat. No.: HY-B2035
CAS No.: 51218-49-6
Target:
Herbicide Environmental Pollutants Caspase Cytochrome P450 MDM-2/p53 Interleukin Related Reactive Oxygen Species (ROS) Apoptosis
Research Areas:
Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish .
Synonyms: DHNQ (Standard); 5,8-Dihydroxy-1,4-naphthoquinone (Standard)
Category:
Quinones Juglandaceae Juglans sigillata Dode Phenols Polyphenols Plants Naphthalene Quinones
Target:
Cat. No.: HY-178940
Research Areas:
Apoptosis inducer 49 is a selective apoptosis inducer with high specificity against CCRF-CEM leukemia cells (IC50 = 2.68 μM). Apoptosis inducer 49 enhances RNA synthesis and replication stress, activates the Chk1-p21 axis, leading to S-phase arrest. Apoptosis inducer 49 can inhibit Bcl-2 and activate caspase-3. Apoptosis inducer 49 can be used for the study of Leukemia .
Cat. No.: HY-110313R
CAS No.: 1781882-72-1
Target:
Research Areas:
SB-747651A (dihydrochloride) (Standard) is the analytical standard of SB-747651A (dihydrochloride). This product is intended for research and analytical applications. SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research .
Cat. No.: HY-P703020
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; stress-activated Protein Kinase JNK1; SAPK1; stress-activated Protein Kinase JNK; JNK1; stress-activated Protein Kinase 1; JNK; JNK21B1/2; stress-activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P705577
Synonyms: MAPK8; JNK-46; Prev. PRKM8; stress-activated Protein Kinase JNK1; SAPK1; stress-activated Protein Kinase JNK; JNK1; stress-activated Protein Kinase 1; JNK; JNK21B1/2; stress-activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:
Human
Source:
E. coli
Cat. No.: HY-P701791
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK10; MAP Kinase 10; Prev. PRKM10; JNK3A; JNK3; stress activated Protein Kinase Beta; P54bSAPK; stress-activated Protein Kinase JNK; P493F12; JNK3 Alpha Protein Kinase; stress-activated Protein Kinase JNK3; C-Jun Kinase 3; stress-activated Protein Kinas
Species:
Human
Source:
E. coli
Cat. No.: HY-P705996
Purity: ≥ 90%, as determined by reducing SDS-PAGE .
Synonyms: MAPK8; JNK-46; Prev. PRKM8; stress-activated Protein Kinase JNK1; SAPK1; stress-activated Protein Kinase JNK; JNK1; stress-activated Protein Kinase 1; JNK; JNK21B1/2; stress-activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
