475-38-7
Chemical Structure
Naphthazarin
Synonym(s): DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone
- CAS. Nr.: 475-38-7
- Formula:C10H6O4
- Molecular Weight:190.15
IUPAC Name: 5,8-dihydroxynaphthalene-1,4-dione
InChIKey: RQNVIKXOOKXAJQ-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=C1C(O)=CC=C2O)=O
Biological Activity: Naphthazarin (DHNQ) is a microtubule depolymerizing agent. Naphthazarin can improve motor function and reduce neuroinflammation in mouse models of Parkinson's disease. Naphthazarin can induce tumor cell apoptosis, autophagy, and cell cycle arrest. Naphthazarin can also induce erythrocyte apoptosis. Naphthazarin can be used in the research of tumors and neurodegenerative diseases[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Naphthazarin | 99.59% | Naphthazarin (DHNQ) is a microtubule depolymerizing agent. Naphthazarin can improve motor function and reduce neuroinflammation in mouse models of Parkinson's disease. Naphthazarin can induce tumor cell apoptosis, autophagy, and cell cycle arrest. Naphthazarin can also induce erythrocyte apoptosis. Naphthazarin can be used in the research of tumors and neurodegenerative diseases. | ||||||||||||||||||||
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Naphthazarin (Standard) | 99.53% | Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects. | ||||||||||||||||||||
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References
- [1]. Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):369-74. [Content Brief]
- [2]. Acharya BR, et al. The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells. Apoptosis. 2011 Sep;16(9):924-39. doi: 10.1007/s10495-011-0613-1 [Content Brief]
- [3]. Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90(9):1842-9. [Content Brief]
