Ramentaceone
Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 14787-38-3
- Formula: C11H8O3
- Molecular Weight:188.18
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
11.9 μM
Compound: 1
|
Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay
|
[PMID: 25059501] |
| HeLa | IC50 |
66.6 μM
Compound: 1
|
Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay
|
[PMID: 25059501] |
| HL-60 | IC50 |
8.75 μM
Compound: 1, 7-methyljuglone
|
Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
|
[PMID: 22250825] |
| HUVEC | ED50 |
5.7 μg/mL
Compound: 9
|
Cytotoxicity against human HUVEC
Cytotoxicity against human HUVEC
|
[PMID: 15270571] |
| KB | ED50 |
4.1 μg/mL
Compound: 9
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 15270571] |
| LNCaP | ED50 |
3.7 μg/mL
Compound: 9
|
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
|
[PMID: 15270571] |
| Lu1 | ED50 |
13.2 μg/mL
Compound: 9
|
Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
|
[PMID: 15270571] |
| MCF7 | IC50 |
27.2 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay
|
[PMID: 25059501] |
| NFF | IC50 |
7.6 μM
Compound: 2
|
Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay
Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay
|
[PMID: 33314932] |
| PBMC | IC50 |
18.4 μM
Compound: 1
|
Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay
|
[PMID: 25059501] |
| Vero | IC50 |
15.1 μg/mL
Compound: 6
|
Cytotoxicity against Vero cells after 48 hrs by XTT method
Cytotoxicity against Vero cells after 48 hrs by XTT method
|
[PMID: 17888665] |
Chemical Information
-
CAS No. 14787-38-3
-
Molecular Weight 188.18
-
Formula C11H8O3
-
SMILES
O=C1C=CC(C2=C1C=C(C)C=C2O)=O
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Synonyms
7-Methyljuglon
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Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)