Isoplumbagin

Cat. No.: HY-W452285: Data Sheet Handling Instructions
FAQs
Technical Support

Isoplumbagin is antimicrobial agent. Isoplumbagin exhibits anticancer activity mainly through modulating mitochondrial dynamics and function.

For research use only. We do not sell to patients.

Isoplumbagin Chemical Structure

CAS No. : 14777-17-4

Size	Price	Stock
50 mg		Ask For Quote & Lead Time
100 mg		Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isoplumbagin is antimicrobial agent. Isoplumbagin exhibits anticancer activity mainly through modulating mitochondrial dynamics and function^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	GI₅₀	2.7 μM Compound: 2	Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
CAL-51	GI₅₀	2.5 μM Compound: 2	Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HCC1954	GI₅₀	0.34 μM Compound: 2	Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HCT-116	GI₅₀	0.46 μM Compound: 2	Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
K562	GI₅₀	1.3 μM Compound: 2	Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MCF7	GI₅₀	1.4 μM Compound: 2	Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MOLM-13	GI₅₀	4.1 μM Compound: 2	Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MV4-11	GI₅₀	26.5 μM Compound: 2	Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
NCI-H1299	IC₅₀	1.5 μM Compound: 143	Cytotoxicity against human NCI-H1299 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human NCI-H1299 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]
PC-3	IC₅₀	6 μM Compound: 143	Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]
U-87MG ATCC	IC₅₀	2.4 μM Compound: 143	Cytotoxicity against human U87 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human U87 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]

Molecular Weight

188.18

Formula

C₁₁H₈O₃

CAS No.

14777-17-4

SMILES

O=C1C(C)=CC(C2=C1C(O)=CC=C2)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tsao YC, et al. Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone. Int J Mol Sci. 2020 Jun 19;21(12):4378. [Content Brief]

Isoplumbagin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoplumbagin14777-17-4AntibioticBacterialNQO1NAD(P)H dehydrogenase quinone 1anti-inflammatoryAnti-CancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *