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Results for "

thiol-groups

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) ADC Payload (1) Amino Acid Derivatives (2) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (73) Cuproptosis (1) DNA Stain (1) Drug Derivative (3) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (5) Environmental Pollutants (1) Fluorescent Dye (17) Fungal (4) Lipocalin Family (1) Liposome (6) Microtubule/Tubulin (1) NADPH Oxidase (1) NF-κB (1) NO Synthase (1) Parasite (2) PROTAC Linkers (5) Reactive Oxygen Species (ROS) (3) Reference Standards (3) STAT (1) ULK (1)
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Oligonucleotides:	Pegylated Lipids (4) Phospholipids (1) Polymers (1)

125

Inhibitors & Agonists

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Biochemical Assay Reagents

Peptides

Natural
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Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15915

DTNB 10+ Cited Publications Ellman’s Reagent	Biochemical Assay Reagents	Others
DTNB (Ellman’s Reagent) is a chemical used to quantify the number or concentration of thiol groups .

HY-138200

Cy5 maleimide 1 Publications Verification Cyanine5 maleimide	DNA Stain Fluorescent Dye	Others
Cy5 maleimide (Cyanine5 maleimide) is a single-reactive dye containing a maleimide group and a CY5 fluorescent group, which can selectively couple with a thiol group. Cy5 maleimide can be used to label antibodies, peptides, or proteins (Ex/Em = 646/664 nm).

HY-135233

N-Succinimidyl-S-acetylthioacetate SATA	Biochemical Assay Reagents	Others
N-Succinimidyl S-acetylthioacetate (SATA) is a protein modifying agent. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form. N-Succinimidyl-S-acetylthioacetate can thiolate antibodies, thereby promoting efficient attachment of antibodies to other molecules and exerting conjugation activity. N-Succinimidyl-S-acetylthioacetate can be used in immunoassays such as ELISA studies .

HY-136386

N-Acetyl-D-cysteine 3 Publications Verification	Reactive Oxygen Species (ROS)	Others
N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .

HY-166648

DSPE-PEG2000-Maleimide sodium (purity>99%) 1 Publications Verification	Liposome	Cancer
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride 2-Maleimidoethylamine hydrochloride	Biochemical Assay Reagents	Cancer
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .

HY-159057

Biotin-BMCC	Biochemical Assay Reagents	Others
Biotin-BMCC is a Maliemide (HY-W007324) conjugated biotin molecule that has a high affinity for free thiol groups of cysteines .

HY-12638

Dichlorophen 1 Publications Verification DDM	Environmental Pollutants Fungal Parasite Bacterial	Infection
Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dye	Others
Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

HY-130080

DM3 Maytansinoid DM3	ADC Payload Microtubule/Tubulin	Cancer
DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs) .

HY-137541

2-Nitro-5-thiocyanatobenzoic acid NTCB	Biochemical Assay Reagents	Others
2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives .

HY-W441004

DSPE-Thiol	Liposome	Others
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .

HY-166648A

DSPE-PEG-Maleimide ammonium (MW 2000) 1 Publications Verification	Liposome	Others
DSPE-PEG-Maleimide ammonium (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG-Maleimide ammonium (MW 2000) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. DSPE-PEG-Maleimide ammonium (MW 2000) is applicable to research on drug delivery .

HY-D1364

Pyrene maleimide	Biochemical Assay Reagents	Others
Pyrene maleimide is a polyaromatic fluorescent hydrocarbon with a termininal maleimide group. The maleimide group will react with a thiol group to form a covalent bond.

HY-D2498

Cy7 maleimide	Fluorescent Dye	Others
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .

HY-156377

Biotin-PEG7-Maleimide	Drug-Linker Conjugates for ADC	Cancer
Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol groups (SH). Biotin-PEG7-Maleimide can be used as Drug-Linker Conjugates for ADCs .

HY-W190932

TAMRA-PEG2-Maleimide	Fluorescent Dye	Others
TAMRA-PEG2-Maleimide is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG2-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.

HY-W800805

DOPE-Mal	Liposome	Cancer
DOPE-Mal is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions with a terminal maliemide group. The maleimide group will react with a thiol group to form a covalent bond. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-W1048849B

4-Arm PEG-SH (MW 10000) 4-Arm PEG-thiol (MW 10000)	Biochemical Assay Reagents	Others
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W872575

TCO4-PEG3-Maleimide	PROTAC Linkers	Cancer
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-W1048849A

4-Arm PEG5000-SH 4-Arm PEG5000-thiol	Biochemical Assay Reagents	Others
4-Arm PEG5000-SH (4-Arm PEG5000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-E70523

Pentanoyl coenzyme A Valeryl-CoA; Valeryl-coenzyme A; Pentanoyl coenzyme A free acid	Endogenous Metabolite	Metabolic Disease
Pentanoyl coenzyme A (Valeryl-CoA) is a short-chain fatty acyl-CoA that functions as an intermediate in mitochondrial β-oxidation and related metabolic pathways. Pentanoyl coenzyme A results from the formal condensation of the thiol group of coenzyme A with the carboxy group of pentanoic acid. Pentanoyl coenzyme A's levels can reflect changes in lipid metabolism under different physiological and pathological conditions. Pentanoyl coenzyme A can be used for research on lipid metabolism .

HY-N9279

Dehydromonocrotaline Monocrotaline pyrrole; MCTP; 3,8-Didehydromonocrotaline	Endogenous Metabolite	Cardiovascular Disease Cancer
Dehydromonocrotaline is a mitochondrial respiratory chain complex I NADH oxidase inhibitor, with a IC₅₀ of 62.06 μM and a K_i of 8.1 μM in rats. Dehydromonocrotaline exerts non-competitive inhibitory effects by modifying cysteine thiol groups on complex I, and does not bind to the NADH-binding site. Dehydromonocrotaline dissipates mitochondrial membrane potential and reduces ATP levels. Dehydromonocrotaline can be used in studies related to hepatotoxicity, pulmonary hypertension and liver tumors .

HY-W736950A

H-L-Cys(MDNPE)-OH hydrochloride	Amino Acid Derivatives	Others
H-L-Cys(MDNPE)-OH hydrochloride is a cysteine derivative with a short peptide sequence attached to the thiol group of cysteine.

HY-W020780D

mPEG40000-Mal	Biochemical Assay Reagents	Others
mPEG40000-Mal is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .

HY-W1048849C

4-Arm PEG20000-SH 4-Arm PEG20000-thiol	Biochemical Assay Reagents	Others
4-Arm PEG20000-SH (4-Arm PEG20000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-134428

Arachidonoyl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .

HY-D2488

Sulfo Cy5.5-maleimide	Fluorescent Dye	Others
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.

HY-E70264

16:0 Coenzyme A triammonium	Endogenous Metabolite	Metabolic Disease
16:0 Coenzyme A triammonium is palmitoyl-CoA, which can serve as a reaction substrate to transfer the palmitoyl group to the free thiol group of the target protein through palmitoylation catalyzed by protein acyl transferases (PATs) .

HY-W1048527

8-Arm PEG5000-SH 8-Arm PEG5000-thiol	Biochemical Assay Reagents	Others
8-Arm PEG5000-SH (8-Arm PEG5000-Thiol) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG5000-SH can be used for drug delivery .

HY-156392

TCO4-PEG7-Maleimide	PROTAC Linkers	Cancer
TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-W590555

Thiol-PEG2000-DMG	Liposome	Cancer
Thiol-PEG2000-DMG is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.

HY-CE00380

(S)-3-Hydroxyoctanoyl-CoA (S)-3-Hydroxyoctanoyl-Coenzyme A	Biochemical Assay Reagents	Metabolic Disease
(S)-3-Hydroxyoctanoyl-CoA ((S)-3-Hydroxyoctanoyl-Coenzyme A) is a hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (S)-3-hydroxyoctanoic acid.

HY-CE00475

(R)-3-Hydroxytetradecanoyl-CoA (R)-3-Hydroxytetradecanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
(R)-3-Hydroxytetradecanoyl-CoA ((R)-3-Hydroxytetradecanoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (R)-3-hydroxytetradecanoic acid.

HY-157920

Biotin-PE-maleimide N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine	Biochemical Assay Reagents	Others
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .

HY-W1048527A

8-Arm PEG20000-SH 8-Arm PEG20000-thiol	Biochemical Assay Reagents	Others
8-Arm PEG20000-SH (8-Arm PEG20000-Thiol) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG20000-SH can be used for drug delivery .

HY-W1048527C

8-Arm PEG10000-SH 8-Arm PEG10000-thiol	Biochemical Assay Reagents	Others
8-Arm PEG10000-SH (8-Arm PEG10000-Thiol) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG10000-SH can be used for drug delivery .

HY-W1048849D

4-Arm PEG40000-SH 4-Arm PEG40000-thiol	Biochemical Assay Reagents	Others
4-Arm PEG40000-SH (4-Arm PEG40000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W591479

MC-Val-Ala-NHS ester	ADC Linker	Cancer
MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group is reactive toward thiol groups. MC is reactive with thiol moieties. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond.

HY-162159

Ac-Cys-NHMe	Amino Acid Derivatives	Others
Ac-Cys-NHMe is a Cys dipeptide with thiol group .

HY-D1526

N-(4-Anilino-1-naphthyl)maleimide	Fluorescent Dye	Others
N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λ_ex=355 nm, λ_em=448 nm .

HY-129994

S-Nitroso-CoA S-Nitroso-coenzyme A; SNO-CoA; SNO-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
S-Nitroso-CoA (S-Nitroso-coenzyme A) is a nitrosothio compound that is coenzyme A in which the thiol group is replaced by a nitrososulfanediyl group .

HY-W395122

Mal-PEG1-PNP-carbonate	Biochemical Assay Reagents	Others
Mal-PEG1-PNP-carbonate is a amine-reactive compound. PNP is a good leaving group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

HY-W800682

Bis-sulfone-PEG4-acid	Biochemical Assay Reagents	Others
Bis-Sulfone-PEG4-acid is a reagent with a sulfone and an acid. The sulfone group can be conjugated with thiol groups of proteins. The terminal acid reacts with primary amines with the help of activators (EDC or HATU) to from stable amide bonds.

HY-CE00399

(S)-3-Hydroxylauroyl-CoA (S)-3-Hydroxylauroyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
(S)-3-Hydroxylauroyl-CoA ((S)-3-Hydroxylauroyl-coenzyme A) is a hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (S)-3-hydroxydodecanoic acid.

HY-CE00476

(R)-3-Hydroxyvaleryl-CoA (3R)-Hydroxyvaleryl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
(R)-3-Hydroxyvaleryl-CoA ((3R)-Hydroxyvaleryl-coenzyme A) is a 3-hydroxy fatty acyl-CoA resulting from the formal condensation of the thiol group of coenzyme A with the carboxy group of (R)-3-hydroxypentanoic acid.

HY-D2103

TAMRA-PEG3-Maleimide	Fluorescent Dye	Others
TAMRA-PEG3-Maleimide is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Maleimide contains maleimide groups that react with thiol groups to form covalent bonds.

HY-D2104

TAMRA-PEG7-Maleimide	Fluorescent Dye	Others
TAMRA-PEG7-Maleimide is a dye derivative of TAMRA (HY-135640) containing 7 PEG units. TAMRA-PEG7-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.

HY-W591975

Alkyne maleimide	Biochemical Assay Reagents	Others
Alkyne maleimide is a bifunctional linker reagent with a terminal malimide group and a propargyl group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

HY-W800817

TCO-PEG4-maleimide	Biochemical Assay Reagents	Others
TCO-PEG4-maleimide is a click chemistry building block containing a TCO moiety and a maleimide group. The maleimide group will react with a thiol group to form a covalent bond. TCO moiety is very reactive with tetrazine (3rd generation click chemistry).

Cat. No.	Product Name	Type

HY-138200

Cy5 maleimide 1 Publications Verification Cyanine5 maleimide	Fluorescent Dyes
Cy5 maleimide (Cyanine5 maleimide) is a single-reactive dye containing a maleimide group and a CY5 fluorescent group, which can selectively couple with a thiol group. Cy5 maleimide can be used to label antibodies, peptides, or proteins (Ex/Em = 646/664 nm).

HY-W998680

Fluorescein-maleimide

5-FITC-Maleimide

Fluorescent Dyes

Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .

HY-D2498

Cy7 maleimide	Fluorescent Dyes
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .

HY-W190932

TAMRA-PEG2-Maleimide	Fluorescent Dyes
TAMRA-PEG2-Maleimide is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG2-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.

HY-D2002

ATTO 488 maleimide

Fluorescent Dyes

ATTO 488 maleimide is a thiol-reactive fluorescent labeling reagent that forms a covalent bond via its maleimide group with the thiol group of the C-terminal cysteine residue of α-synGC. ATTO 488 maleimide enables α-syn fiber imaging via super-resolution stimulated emission depletion (STED) fluorescence microscopy. ATTO 488 maleimide is applicable to research related to Parkinson's disease (Ex/Em = 488/592nm) .

HY-D2488

Sulfo Cy5.5-maleimide	Fluorescent Dyes
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.

HY-D1526

N-(4-Anilino-1-naphthyl)maleimide	Fluorescent Dyes
N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λ_ex=355 nm, λ_em=448 nm .

HY-D2103

TAMRA-PEG3-Maleimide	Fluorescent Dyes
TAMRA-PEG3-Maleimide is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Maleimide contains maleimide groups that react with thiol groups to form covalent bonds.

HY-D2104

TAMRA-PEG7-Maleimide	Fluorescent Dyes
TAMRA-PEG7-Maleimide is a dye derivative of TAMRA (HY-135640) containing 7 PEG units. TAMRA-PEG7-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.

HY-D2150

AF 430 maleimide	Fluorescent Dyes
AF 430 maleimide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 maleimide contains maleimide groups that react with thiol groups to form covalent bonds. To achieve specific coupling of dye labels and biomolecules .

HY-D2091

PE-VF647 Maleimide	Fluorescent Dyes
PE-VF647 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. PE-VF647 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 665 nm.

HY-D2093

PE-VF750 Maleimide	Fluorescent Dyes
PE-VF750 Maleimide is a thiol-reactive double-dye dye that contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/777 nm. PE-VF750 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 777 nm.

HY-D2092

PE-VF680 Maleimide	Fluorescent Dyes
PE-VF680 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/701 nm. PE-VF680 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 701 nm.

HY-D3052

5(6)-carbonylated rhodamine 110 maleimide	Fluorescent Dyes
5(6)-carbonylated rhodamine 110 maleimide is a maleimide-based fluorescent reagent based on 5(6)-carbonylated rhodamine 110. Maleimide can be labeled by forming a stable thioester structure through an affinity addition reaction with a thiol group (-SH) (Ex/Em = 502/527 nm).

HY-D3056

5(6)-Rhodamine 6G maleimide	Fluorescent Dyes
5(6)-Rhodamine 6G maleimide is a maleimide-based fluorescent reagent based on Rhodamine 6G (HY-D0309). Maleimide can be labeled by forming a stable thioester structure through an affinity addition reaction with a thiol group (-SH) (Ex/Em = 526/547 nm).

HY-D3200

Dns–LLC

Fluorescent Dyes

Dns-LLC is a cell-permeable Cu ⁺-selective fluorescent probe that forms a 1:1 complex with Cu ⁺. The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu ⁺ in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu ⁺ in the Golgi apparatus .

HY-D2763

BP Fluor 532 maleimide

Fluorescent Dyes

BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry. Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.

Cat. No.	Product Name	Type

HY-15915

DTNB 10+ Cited Publications Ellman’s Reagent	Biochemical Assay Reagents
DTNB (Ellman’s Reagent) is a chemical used to quantify the number or concentration of thiol groups .

HY-135233

N-Succinimidyl-S-acetylthioacetate

SATA

Biochemical Assay Reagents

N-Succinimidyl S-acetylthioacetate (SATA) is a protein modifying agent. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form. N-Succinimidyl-S-acetylthioacetate can thiolate antibodies, thereby promoting efficient attachment of antibodies to other molecules and exerting conjugation activity. N-Succinimidyl-S-acetylthioacetate can be used in immunoassays such as ELISA studies .

HY-NP008

β-Lactoglobulin

Biochemical Assay Reagents

β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

HY-166648

DSPE-PEG2000-Maleimide sodium (purity>99%) 1 Publications Verification	Biochemical Assay Reagents
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride

2-Maleimidoethylamine hydrochloride

Biochemical Assay Reagents

N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .

HY-W440896

DSPE-PEG2000-SH

Biochemical Assay Reagents

DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .

HY-W591476

m-PEG1000-thiol

mPEG1000-SH

Biochemical Assay Reagents

m-PEG1000-thiol is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].

HY-W441004

DSPE-Thiol	Biochemical Assay Reagents
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .

HY-D1364

Pyrene maleimide	Biochemical Assay Reagents
Pyrene maleimide is a polyaromatic fluorescent hydrocarbon with a termininal maleimide group. The maleimide group will react with a thiol group to form a covalent bond.

HY-W1048849B

4-Arm PEG-SH (MW 10000) 4-Arm PEG-thiol (MW 10000)	Biochemical Assay Reagents
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W1048849A

4-Arm PEG5000-SH 4-Arm PEG5000-thiol	Biochemical Assay Reagents
4-Arm PEG5000-SH (4-Arm PEG5000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W1048555A

Mal-PEG2000-SCM

Biochemical Assay Reagents

Mal-PEG2000-SCM is a heterobifunctional PEG crosslinker bearing maleimide and succinimidyl carboxymethyl ester functional groups. MMal-PEG2000-SCM conjugates the F3 peptide to nanoparticles: the SCM group reacts with amino groups on the nanoparticle surface to form amide groups, while the MAL group reacts with thiol groups of the F3 peptide to form carbon-sulfur bonds. Mal-PEG-SCM enables unidirectional addition of linkers, ensuring that appropriate functional groups are available for RGD incorporation. Mal-PEG2000-SCM can be used in the development of nanoparticles targeting specific tumor cells .

HY-W020780D

mPEG40000-Mal	Biochemical Assay Reagents
mPEG40000-Mal is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .

HY-W1048849C

4-Arm PEG20000-SH 4-Arm PEG20000-thiol	Biochemical Assay Reagents
4-Arm PEG20000-SH (4-Arm PEG20000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-134428

Arachidonoyl coenzyme A lithium	Biochemical Assay Reagents
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .

HY-W1048527

8-Arm PEG5000-SH 8-Arm PEG5000-thiol	Biochemical Assay Reagents
8-Arm PEG5000-SH (8-Arm PEG5000-Thiol) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG5000-SH can be used for drug delivery .

HY-157920

Biotin-PE-maleimide N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine	Biochemical Assay Reagents
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .

HY-W1048527A

8-Arm PEG20000-SH 8-Arm PEG20000-thiol	Biochemical Assay Reagents
8-Arm PEG20000-SH (8-Arm PEG20000-Thiol) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG20000-SH can be used for drug delivery .

HY-W1048527C

8-Arm PEG10000-SH 8-Arm PEG10000-thiol	Biochemical Assay Reagents
8-Arm PEG10000-SH (8-Arm PEG10000-Thiol) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG10000-SH can be used for drug delivery .

HY-W1048849D

4-Arm PEG40000-SH 4-Arm PEG40000-thiol	Biochemical Assay Reagents
4-Arm PEG40000-SH (4-Arm PEG40000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-168938

Poly(ethylene glycol) methyl ether maleimide (Mn 2000)	Biochemical Assay Reagents
Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing Maleimide (HY-W007324). Due to the Maleimide functional group, Poly(ethylene glycol) methyl ether maleimide (Mn 2000) can be used to conjugate biomolecules containing thiol groups.

HY-174949B

FMOC-NH-PEG3400-SH

FMOC-NH-PEG3400-thiol

Biochemical Assay Reagents

FMOC-NH-PEG3400-SH (FMOC-NH-PEG3400-Thiol) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-W060216

N-Acetyl-DL-penicillamine

Biochemical Assay Reagents

2-Acetamido-3-methyl-3-sulfanylbutanoic acid is an organic compound that belongs to the class of amino acids. It is a derivative of methionine, an essential amino acid commonly found in various foods. 2-Acetamido-3-methyl-3-sulfanylbutanoic acid contains a thiol group and an acetamido group at specific positions in the amino acid chain. It has various applications in the food industry, especially as a flavor enhancer and umami seasoning. Additionally, it has potential research utility in liver disease and other metabolic disorders.

HY-182841D

DMPE-PEG10000-SH DMPE-PEG10000-thiol	Biochemical Assay Reagents
DMPE-PEG10000-SH (DMPE-PEG10000-Thiol) is a conjugate composed of DMPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DMPE-PEG10000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182882D

DPPE-PEG10000-SH DPPE-PEG10000-thiol	Biochemical Assay Reagents
DPPE-PEG10000-SH (DPPE-PEG10000-Thiol) is a conjugate composed of DPPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DPPE-PEG10000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-183055D

DSG-PEG10000-SH DSG-PEG10000-thiol	Biochemical Assay Reagents
DSE-PEG10000-SH (DSE-PEG10000-Thiol) is a conjugate composed of DSE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DSE-PEG10000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182841C

DMPE-PEG5000-SH DMPE-PEG5000-thiol	Biochemical Assay Reagents
DMPE-PEG5000-SH (DMPE-PEG5000-Thiol) is a conjugate composed of DMPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DMPE-PEG5000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-183055A

DSG-PEG2000-SH DSG-PEG2000-thiol	Biochemical Assay Reagents
DSE-PEG2000-SH (DSE-PEG2000-Thiol) is a conjugate composed of DSE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DSE-PEG2000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182882A

DPPE-PEG2000-SH DPPE-PEG2000-thiol	Biochemical Assay Reagents
DPPE-PEG2000-SH (DPPE-PEG2000-Thiol) is a conjugate composed of DPPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DPPE-PEG2000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-183055B

DSG-PEG3400-SH DSG-PEG3400-thiol	Biochemical Assay Reagents
DSE-PEG3400-SH (DSE-PEG3400-Thiol) is a conjugate composed of DSE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DSE-PEG3400-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182882C

DPPE-PEG5000-SH DPPE-PEG5000-thiol	Biochemical Assay Reagents
DPPE-PEG5000-SH (DPPE-PEG5000-Thiol) is a conjugate composed of DPPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DPPE-PEG5000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-183055C

DSG-PEG5000-SH DSG-PEG5000-thiol	Biochemical Assay Reagents
DSE-PEG5000-SH (DSE-PEG5000-Thiol) is a conjugate composed of DSE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DSE-PEG5000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182882

DPPE-PEG1000-SH DPPE-PEG1000-thiol	Biochemical Assay Reagents
DPPE-PEG1000-SH (DPPE-PEG1000-Thiol) is a conjugate composed of DPPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DPPE-PEG1000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-183055

DSG-PEG1000-SH DSG-PEG1000-thiol	Biochemical Assay Reagents
DSE-PEG1000-SH (DSE-PEG1000-Thiol) is a conjugate composed of DSE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DSE-PEG1000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182841

DMPE-PEG1000-SH DMPE-PEG1000-thiol	Biochemical Assay Reagents
DMPE-PEG1000-SH (DMPE-PEG1000-Thiol) is a conjugate composed of DMPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DMPE-PEG1000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182882B

DPPE-PEG3400-SH DPPE-PEG3400-thiol	Biochemical Assay Reagents
DPPE-PEG3400-SH (DPPE-PEG3400-Thiol) is a conjugate composed of DPPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DPPE-PEG3400-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-182841A

DMPE-PEG2000-SH DMPE-PEG2000-thiol	Biochemical Assay Reagents
DMPE-PEG2000-SH (DMPE-PEG2000-Thiol) is a conjugate composed of DMPE, a PEG chain, and a terminal thiol group (-SH). The thiol group in DMPE-PEG2000-SH exhibits strong chemical reactivity and can participate in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

HY-W591469

mPEG1000-Mal	Biochemical Assay Reagents
mPEG1000-Mal is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .

HY-W1048527B

8-Arm PEG40000-SH 8-Arm PEG40000-thiol	Biochemical Assay Reagents
8-Arm PEG40000-SH (8-Arm PEG40000-Thiol) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG40000-SH can be used for drug delivery .

HY-174949C

FMOC-NH-PEG5000-SH

FMOC-NH-PEG5000-thiol

Biochemical Assay Reagents

FMOC-NH-PEG5000-SH (FMOC-NH-PEG5000-Thiol) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949D

FMOC-NH-PEG10000-SH

FMOC-NH-PEG10000-thiol

Biochemical Assay Reagents

FMOC-NH-PEG10000-SH (FMOC-NH-PEG10000-Thiol) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949

FMOC-NH-PEG1000-SH

FMOC-NH-PEG1000-thiol

Biochemical Assay Reagents

FMOC-NH-PEG1000-SH (FMOC-NH-PEG1000-Thiol) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949A

FMOC-NH-PEG2000-SH

FMOC-NH-PEG2000-thiol

Biochemical Assay Reagents

FMOC-NH-PEG2000-SH (FMOC-NH-PEG2000-Thiol) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-W1048549H

HOOC-PEG1000-SH

HOOC-PEG1000-thiol

Biochemical Assay Reagents

HOOC-PEG1000-SH (HOOC-PEG1000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549J

HOOC-PEG40000-SH

HOOC-PEG40000-thiol

Biochemical Assay Reagents

HOOC-PEG40000-SH (HOOC-PEG40000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

Cat. No.	Product Name	Target	Research Area

HY-P4094

CTP 2 Publications Verification Cardiac targeting peptide	Peptides	Cardiovascular Disease
CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs .

HY-P11308

Cys-GE11	EGFR	Cancer
Cys-GE11 is an N-terminal modified GE11 (HY-P10128) with cysteine (Cys) added. Cys-GE11 can be coupled through the thiol group of Cys. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells). Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity .

HY-P11781A

Cys-HW12	Drug Derivative	Cancer
Cys-HW12 is a random peptide containing an N-terminal cysteine. Cys-HW12 can be coupled via the thiol group of Cys. Cys-HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 is applicable to pancreatic cancer-related research .

HY-P11781B

Cys-HW12 TFA	Drug Derivative	Cancer
Cys-HW12 TFA is a random peptide containing an N-terminal cysteine and derivative of HW12 (HY-P11781). Cys-HW12 TFA can be coupled via the thiol group of Cys. Cys-HW12 TFA can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 TFA is applicable to pancreatic cancer-related research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9279

Dehydromonocrotaline Monocrotaline pyrrole; MCTP; 3,8-Didehydromonocrotaline	Pyrrolizidine Alkaloids Structural Classification Alkaloids Endogenous metabolite Source Classification	Endogenous Metabolite
Dehydromonocrotaline is a mitochondrial respiratory chain complex I NADH oxidase inhibitor, with a IC₅₀ of 62.06 μM and a K_i of 8.1 μM in rats. Dehydromonocrotaline exerts non-competitive inhibitory effects by modifying cysteine thiol groups on complex I, and does not bind to the NADH-binding site. Dehydromonocrotaline dissipates mitochondrial membrane potential and reduces ATP levels. Dehydromonocrotaline can be used in studies related to hepatotoxicity, pulmonary hypertension and liver tumors .

HY-136386R

N-Acetyl-D-cysteine (Standard)	Microorganisms Source Classification	Reference Standards Reactive Oxygen Species (ROS)
N-Acetyl-D-cysteine (Standard) is the analytical standard of N-Acetyl-D-cysteine. This product is intended for research and analytical applications. N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .

HY-N19808

2-Deacetyl-4-tigloylchamissionolide	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Source Classification	Drug Derivative
2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .

Cat. No.	Product Name		Classification

HY-W872575

TCO4-PEG3-Maleimide		TCO PROTAC Synthesis
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-156392

TCO4-PEG7-Maleimide		TCO PROTAC Synthesis
TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-156391A

(R)-TCO4-PEG2-Maleimide		TCO
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-156391

TCO4-PEG2-Maleimide		TCO
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-W872575A

(R)-TCO4-PEG3-Maleimide		TCO
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

HY-W591360

Iodoacetamido-PEG6-azide		Azide
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

HY-183022

3-Azidopropyl-1-maleimide		Azide
1-(3-Azidopropyl)-1H-pyrrole-2,5-dione is a maleimide derivative with a 3-azidopropyl substituent, used to introduce an azide functional group to bovine serum albumin (BSA). 1-(3-Azidopropyl)-1H-pyrrole-2,5-dione reacts with the free, solvent-accessible thiol group of BSA to produce azide-functionalized BSA, which is used in click chemistry to form a TLL-BSA hetero-dimer .

Cat. No.	Product Name		Classification

HY-166648

DSPE-PEG2000-Maleimide sodium (purity>99%) 1 Publications Verification		Pegylated Lipids
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .

HY-W440896

DSPE-PEG2000-SH		Pegylated Lipids
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .

HY-W591476

m-PEG1000-thiol mPEG1000-SH		Polymers
m-PEG1000-thiol is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].

HY-W441004

DSPE-Thiol		Phospholipids
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .

HY-166648A

DSPE-PEG-Maleimide ammonium (MW 2000) 1 Publications Verification		Pegylated Lipids
DSPE-PEG-Maleimide ammonium (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG-Maleimide ammonium (MW 2000) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. DSPE-PEG-Maleimide ammonium (MW 2000) is applicable to research on drug delivery .

HY-W590555

Thiol-PEG2000-DMG		Pegylated Lipids
Thiol-PEG2000-DMG is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.

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