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Results for "

tri-peptide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) ADC Linker (2) ADC Payload (3) Akt (1) Amino Acid Derivatives (12) Aminopeptidase (3) Amyloid-β (2) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (3) Apoptosis (10) Bacterial (10) Bcl-2 Family (1) Beta-secretase (1) Biochemical Assay Reagents (14) Cathepsin (5) Collagen (1) Dipeptidyl Peptidase (1) Drug Derivative (1) Drug Intermediate (2) Drug-Linker Conjugates for ADC (1) Elastase (1) FAP (1) Fungal (5) Glutathione Peroxidase (1) Glutathione S-transferase (2) GnRH Receptor (1) Herbicide (1) Histone Demethylase (1) HIV (1) HSV (3) iGluR (2) Integrin (2) Interleukin Related (2) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Melanocortin Receptor (2) mGluR (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) MMP (2) Neurokinin Receptor (2) Neuropeptide Y Receptor (1) NF-κB (3) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) P-selectin (1) PDK-1 (1) Proteasome (2) PTEN (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) SARS-CoV (3) Ser/Thr Protease (1) Sirtuin (1) TGF-β Receptor (1) Toll-like Receptor (TLR) (1) Tyrosinase (1) Virus Protease (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (10) Endocrinology (2) Infection (21) Inflammation/Immunology (16) Metabolic Disease (12) Neurological Disease (16)

By Targets:

Acetyl-CoA Carboxylase (1)

ADC Linker (2)

ADC Payload (3)

Akt (1)

Amino Acid Derivatives (12)

Aminopeptidase (3)

Amyloid-β (2)

Angiotensin-converting Enzyme (ACE) (5)

Antibiotic (3)

Apoptosis (10)

Bacterial (10)

Bcl-2 Family (1)

Beta-secretase (1)

Biochemical Assay Reagents (14)

Cathepsin (5)

Collagen (1)

Dipeptidyl Peptidase (1)

Drug Derivative (1)

Drug Intermediate (2)

Drug-Linker Conjugates for ADC (1)

Elastase (1)

FAP (1)

Fungal (5)

Glutathione Peroxidase (1)

Glutathione S-transferase (2)

GnRH Receptor (1)

Herbicide (1)

Histone Demethylase (1)

HIV (1)

HSV (3)

iGluR (2)

Integrin (2)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

MDM-2/p53 (1)

Melanocortin Receptor (2)

mGluR (1)

Microtubule/Tubulin (4)

Mitochondrial Metabolism (1)

MMP (2)

Neurokinin Receptor (2)

Neuropeptide Y Receptor (1)

NF-κB (3)

NO Synthase (1)

Nucleoside Antimetabolite/Analog (1)

P-selectin (1)

PDK-1 (1)

Proteasome (2)

PTEN (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

SARS-CoV (3)

Ser/Thr Protease (1)

Sirtuin (1)

TGF-β Receptor (1)

Toll-like Receptor (TLR) (1)

Tyrosinase (1)

Virus Protease (1)

By Research Areas:

Cancer (23)

Cardiovascular Disease (10)

Endocrinology (2)

Infection (21)

Inflammation/Immunology (16)

Metabolic Disease (12)

Neurological Disease (16)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Copper tripeptide 1 Publications Verification GHK-Cu	Biochemical Assay Reagents	Inflammation/Immunology
Copper tripeptide (GHK-Cu) is a *tripeptide. During wound healing, Copper tripeptide* may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .

RGD Maximum Cited Publications 8 Publications Verification	Integrin	Cancer
RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.

Trofinetide 2 Publications Verification NNZ-2566	iGluR	Neurological Disease
Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.

Ezatiostat Maximum Cited Publications 8 Publications Verification TER199free base; TLK199	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment .

Taltobulin 3 Publications Verification HTI-286; SPA-110	Microtubule/Tubulin ADC Payload Apoptosis	Cancer
Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .

Z-LVG-CHN2 2 Publications Verification	Cathepsin HSV SARS-CoV	Infection Inflammation/Immunology
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease .

*Biotinoyl tripeptide-1* Biotinyl-GHK; Bio-GHK	Amyloid-β Reactive Oxygen Species (ROS)	Neurological Disease
Biotinoyl tripeptide-1 (Biotinyl-GHK) is a biotinylating reagent linked to a GHK (glycyl-L-histidyl-L-lysine) tripeptide. Biotin tripeptide-1 is a bioactive peptide with hair care (improves the appearance and feel of hair) and hair growth effects. Biotinoyl tripeptide-1 has a certain affinity for streptavidin. Biotinoyl tripeptide-1 inhibits the production of ROS and has antioxidant effects. Biotinoyl tripeptide-1 reduces the production of carbonylated amyloid-β (Aβ) and inhibits Aβ aggregation. Biotinoyl tripeptide-1 can be used in the study of neurodegenerative diseases .

Trilysine Lys-Lys-Lys; H-Lys-Lys-Lys-OH	Biochemical Assay Reagents	Others
Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

H-Gly-Gly-Phe-OH	ADC Linker	Cancer
H-Gly-Gly-Phe-OH is a tripeptide linker that may be used in the creation of antibody drug conjugates (ADCs). The N-terminal of the glycine tripeptide is free to perform a variety of reactions such as couplings with carboxylic acids or NHS esters.

H-Gly-Gly-Gly-OH triglycine	Biochemical Assay Reagents	Others
H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.

DM21	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
DM21 is a next-generation linker-payload that combines a maytansinoid microtubule-disrupting payload with a stable tripeptide linker. DM21 is conjugated with a humanized antibody against ADAM9 to obtain IMGC936 .

H-Trp-Trp-Trp-OH Trp-Trp-Trp	Bacterial	Infection
H-Trp-Trp-Trp-OH (Trp-Trp-Trp) is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity. H-Trp-Trp-Trp-OH is a human bitter taste receptor hTAS2R14 agonist .

Gly-Ala-Tyr H-Gly-Ala-Tyr-OH	Biochemical Assay Reagents Bacterial	Others
Gly-Ala-Tyr (H-Gly-Ala-Tyr-OH) is a tripeptide substrate composed of L-glycine, alanine, and L-tyrosine joined in sequence by peptide linkages. Gly-Ala-Tyr can be hydrolyzed at both extracellular and intracellular levels by Streptococcus thermophilus, Lactobacillus delbrueckii ssp. bulgaricus, Lactobacillus acidophilus, and Bifidobacterium spp. Ala-Gly-Tyr is functionally related to L-alanine, glycine and L-tyrosine. .

Neuropeptide Y (3-36) (human, rat) 1 Publications Verification	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides ^[1] ^[2].

Odatroltide LT3001; DHDMIQK(KAP)	P-selectin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .

α-MSH (11-13) acetate ACTH-(11-13) acetate; Lys-Pro-Val acetate; H-Lys-Pro-Val-OH acetate	Melanocortin Receptor NF-κB Bacterial Interleukin Related Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
α-MSH (11-13) (ACTH-(11-13)) acetate is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) acetate exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) acetate also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) acetate can be used in research related to traumatic brain injury, fever, and bacterial infections .

Tripeptide-41 CG-Lipoxyn	NF-κB Histone Demethylase	Metabolic Disease
Tripeptide-41 (CG-Lipoxyn) is a signal peptide. Tripeptide-41 activates the NF-kB signaling pathway, inhibits the expression of C/EBP and increases cAMP. Tripeptide-41 is an important intracellular signaling factor that causes lipolysis by promoting the hydrolysis of lipids into triglycerides. Tripeptide-41 can be used in cosmetics that targets fat accumulation .

*Palmitoyl tripeptide-38*	Collagen	Metabolic Disease
Palmitoyl tripeptide-38 is a lipopeptide that increases the production of dermal and epidermal collagen, fibronectin, and hyaluronic acid. Palmitoyl tripeptide-38 is used in research related to skin aging (fine lines, wrinkles, reduced skin elasticity, decreased skin water content, uneven skin tone) .

*Copper tripeptide-3* AHK-Cu	Others Bcl-2 Family	Others
Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect. Copper tripeptide-3 increases dermal cell proliferation and viability while increasing the deposition of collagen to renew the extracellular matrix. Copper tripeptide-3 stimulates the elongation of human hair follicles and proliferation of dermal papilla cells .

*Palmitoyl tripeptide-5*	MMP	Others
Palmitoyl tripeptide-5 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

RGD Trifluoroacetate Maximum Cited Publications 8 Publications Verification	Integrin	Cancer
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.

Glu-Glu H-Glu-Glu-OH; Glutamyl-glutamic acid	Amino Acid Derivatives	Others
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption .

Troriluzole BHV-4157	mGluR	Neurological Disease Cancer
Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .

PR-924	Proteasome Apoptosis	Cancer
PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC₅₀ of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities .

Gly-Pro-Glu	iGluR	Neurological Disease
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC₅₀ value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

Fmoc-His(3-Me)-OH	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease .

ACV Tripeptide	Drug Intermediate	Infection
ACV Tripeptide, a tripeptide, is the first dedicated intermediate in the biosynthetic pathway leading to the penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. ACV Tripeptide is is synthesized nonribosomally by the ACV synthetase (ACVS) enzyme, which is encoded by the 11 kb The pchAB gene encodes this enzyme. ACV Tripeptide can be used for the biosynthesis of β-lactam antibiotics .

N-Acetyl lysyltyrosylcysteine amide 2 Publications Verification	Glutathione Peroxidase	Cardiovascular Disease Neurological Disease
N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation .

H-Gly-Oet	Biochemical Assay Reagents	Others
H-Gly-Oet can be coupled with Z-Pro-Leu-OEt for the synthesis of tripeptide Z-Pro-Leu-Gly-OEt by thermolysin and α-chymotrypsin catalysis .

H-Gly-Pro-Gly-OH Gly-Pro-Gly	Amino Acid Derivatives	Others
H-Gly-Pro-Gly-OH is a tripeptide containing glycine and proline. H-Gly-Pro-Gly-OH can be used for the synthesis of other polypeptides, such as (Pro Gly Gly)_n .

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

DG013A formate	Aminopeptidase	Inflammation/Immunology Cancer
DG013A (formate) is a phosphinic acid tripeptide mimetic inhibitor. DG013A (formate) displays significantly weak affinity for both ERAP1 (IC₅₀=33 nM) and ERAP2 (IC₅₀=11 nM). DG013A (formate) can be used for the research of autoimmune disease and cancer .

Tyroserleutide hydrochloride	PTEN PDK-1 MDM-2/p53 Apoptosis Akt	Cancer
Tyroserleutide hydrochloride is a tripeptide isolated from the degradation products of porcine spleen with antitumor activity. Tyroserleutide hydrochloride can upregulate the expression of the tumor suppressor gene PTEN and inhibit the activity of AKT and PDK1. Tyroserleutide hydrochloride inhibits tumor cell proliferation and MDM2 phosphorylation by inhibiting the PI3K/AKT pathway, and also upregulates P21, P27, P53, and induces mitochondrial damage and cell apoptosis .

α-MSH (11-13) ACTH-(11-13); Lys-Pro-Val; H-Lys-Pro-Val-OH	Melanocortin Receptor Bacterial NF-κB Apoptosis Interleukin Related	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections .

Gly-His-Lys acetate	Biochemical Assay Reagents Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Gly-His-Lys acetate is a natural, circulating regulatory and antimicrobial tripeptide derived from extracellular matrix proteins. Gly-His-Lys acetate binds Cu ²⁺ to support copper enzyme activation, antioxidant processes, cellular bioenergetics, and the synthesis of elastin, collagen and catecholamines. Gly-His-Lys acetate regulates cell growth, differentiation and tissue repair, and exerts regenerative, anxiolytic, anti-inflammatory, analgesic and immunosuppressive activities. Gly-His-Lys acetate induces liver degenerative changes. Gly-His-Lys acetate can be used for the research of infections, anxiety, pain-related behaviors and immune-associated liver diseases .

Fmoc-Gly-Gly-Gly-OH	Amino Acid Derivatives	Others
Fmoc-Gly-Gly-Gly-OH is a tripeptide that can be used in peptide synthesis.

H-Ile-Pro-Pro-OH hydrochloride 1 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide , inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM . Antihypertensive tripeptides .

F0911-7667	Sirtuin	Cancer
F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments .

IRW	Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism	Inflammation/Immunology
IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation .

*Diaminopropionoyl tripeptide-33*	Tyrosinase	Metabolic Disease
Diaminopropionoyl tripeptide-33isa bioactive peptide with protects skin cells from UVA-induced DNA damages and has been reported used as a cosmetic ingredient .

Tripeptide YYY	Amino Acid Derivatives	Others
(S)-2-((S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoic acid is a tyrosine derivative .

Gly-Leu-Met-NH2	Neurokinin Receptor	Neurological Disease
Gly-Leu-Met-NH2 is a C-terminal tripeptide of Substance P (HY-P0201). Substance P is a neuropeptide .

H-Gly-Gly-Tyr-OH Gly-Gly-Tyr	Biochemical Assay Reagents	Others
H-Gly-Gly-Tyr-OH is a tripeptide that plays an important role in various biochemical applications. H-Gly-Gly-Tyr-OH can be used in the fields of pharmaceuticals and biochemistry .

Threonyl-seryl-lysine	GnRH Receptor	Endocrinology
Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5 .

Taltobulin trifluoroacetate 3 Publications Verification HTI-286 trifluoroacetate; SPA-110 trifluoroacetate	Microtubule/Tubulin ADC Payload Apoptosis	Cancer
Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .

DG013A	Aminopeptidase	Inflammation/Immunology Cancer
DG013A is a phosphinic acid tripeptide mimetic inhibitor. DG013A displays significantly weak affinity for both ERAP1 (IC₅₀=33 nM) and ERAP2 (IC₅₀=11 nM). DG013A can be used for the research of autoimmune disease and cancer .

Cat. No.	Product Name	Type

HY-W015236

H-Gly-Gly-Gly-OH

triglycine

Biochemical Assay Reagents

H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.

HY-143686

ImmTher	Biochemical Assay Reagents
ImmTher is a liposome-encapsulated lipophilic disaccharide tripeptide derivative of muramyl dipeptide. ImmTher can up-regulate specific monocyte cytokine genes and activate monocyte-mediated tumoricidal activity .

HY-W015236R

H-Gly-Gly-Gly-OH (Standard)

triglycine (Standard)

Biochemical Assay Reagents

H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.

Cat. No.	Product Name	Target	Research Area

HY-P0063

Copper tripeptide 1 Publications Verification GHK-Cu	Biochemical Assay Reagents	Inflammation/Immunology
Copper tripeptide (GHK-Cu) is a *tripeptide. During wound healing, Copper tripeptide* may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .

HY-P0278

RGD Maximum Cited Publications 8 Publications Verification	Integrin	Cancer
RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.

HY-A0299

H-Gly-Pro-Hyp-OH tripeptide 29	Peptides	Inflammation/Immunology
H-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis .

HY-P0046

Glycyl-L-histidyl-L-lysine 2 Publications Verification GHK; tripeptide-1	Peptides	Neurological Disease Inflammation/Immunology
Glycyl-L-histidyl-L-lysine is a *tripeptide* consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance .

HY-16757

Trofinetide 2 Publications Verification NNZ-2566	iGluR	Neurological Disease
Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.

HY-13634A

Ezatiostat Maximum Cited Publications 8 Publications Verification TER199free base; TLK199	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment .

HY-P0047

*Palmitoyl Tripeptide-1*	Peptides	Others
Palmitoyl tripeptide-1 is a fatty acid modified polypeptide. Palmitoyl Tripeptide-1 has good wrinkle-removing effect .

HY-125616

*Biotinoyl tripeptide-1* Biotinyl-GHK; Bio-GHK	Amyloid-β Reactive Oxygen Species (ROS)	Neurological Disease
Biotinoyl tripeptide-1 (Biotinyl-GHK) is a biotinylating reagent linked to a GHK (glycyl-L-histidyl-L-lysine) tripeptide. Biotin tripeptide-1 is a bioactive peptide with hair care (improves the appearance and feel of hair) and hair growth effects. Biotinoyl tripeptide-1 has a certain affinity for streptavidin. Biotinoyl tripeptide-1 inhibits the production of ROS and has antioxidant effects. Biotinoyl tripeptide-1 reduces the production of carbonylated amyloid-β (Aβ) and inhibits Aβ aggregation. Biotinoyl tripeptide-1 can be used in the study of neurodegenerative diseases .

HY-W009004

Trilysine Lys-Lys-Lys; H-Lys-Lys-Lys-OH	Biochemical Assay Reagents	Others
Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

HY-P5238

*Trifluoroacetyl tripeptide-2*	Peptides	Others
Trifluoroacetyl tripeptide-2 is a tripeptide with strong cosmetic activity. Trifluoroacetyl tripeptide-2 can regulate progerin synthesis, promote extracellular matrix synthesis, and improve skin elasticity. Trifluoroacetyl tripeptide-2 has anti-wrinkle and firming effects and can be used as an anti-aging ingredient in cosmetic research .

HY-P4648

H-Trp-Trp-Trp-OH Trp-Trp-Trp	Bacterial	Infection
H-Trp-Trp-Trp-OH (Trp-Trp-Trp) is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity. H-Trp-Trp-Trp-OH is a human bitter taste receptor hTAS2R14 agonist .

HY-P3752

Gly-Ala-Tyr H-Gly-Ala-Tyr-OH	Biochemical Assay Reagents Bacterial	Others
Gly-Ala-Tyr (H-Gly-Ala-Tyr-OH) is a tripeptide substrate composed of L-glycine, alanine, and L-tyrosine joined in sequence by peptide linkages. Gly-Ala-Tyr can be hydrolyzed at both extracellular and intracellular levels by Streptococcus thermophilus, Lactobacillus delbrueckii ssp. bulgaricus, Lactobacillus acidophilus, and Bifidobacterium spp. Ala-Gly-Tyr is functionally related to L-alanine, glycine and L-tyrosine. .

HY-P2543

Neuropeptide Y (3-36) (human, rat) 1 Publications Verification	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides ^[1] ^[2].

HY-132828

Odatroltide LT3001; DHDMIQK(KAP)	P-selectin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .

HY-129724A

α-MSH (11-13) acetate ACTH-(11-13) acetate; Lys-Pro-Val acetate; H-Lys-Pro-Val-OH acetate	Melanocortin Receptor NF-κB Bacterial Interleukin Related Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
α-MSH (11-13) (ACTH-(11-13)) acetate is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) acetate exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) acetate also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) acetate can be used in research related to traumatic brain injury, fever, and bacterial infections .

HY-P5244

Tripeptide-32	Peptides	Metabolic Disease
Tripeptide-32 is a bioactive peptide that targets the PER1 gene. Tripeptide-32 can regulate circadian rhythms and stimulate the synthesis of cellular repair proteins, with anti-aging activity .

HY-P5275

Tripeptide-41 CG-Lipoxyn	NF-κB Histone Demethylase	Metabolic Disease
Tripeptide-41 (CG-Lipoxyn) is a signal peptide. Tripeptide-41 activates the NF-kB signaling pathway, inhibits the expression of C/EBP and increases cAMP. Tripeptide-41 is an important intracellular signaling factor that causes lipolysis by promoting the hydrolysis of lipids into triglycerides. Tripeptide-41 can be used in cosmetics that targets fat accumulation .

HY-P0104

*Palmitoyl tripeptide-38*	Collagen	Metabolic Disease
Palmitoyl tripeptide-38 is a lipopeptide that increases the production of dermal and epidermal collagen, fibronectin, and hyaluronic acid. Palmitoyl tripeptide-38 is used in research related to skin aging (fine lines, wrinkles, reduced skin elasticity, decreased skin water content, uneven skin tone) .

HY-P5243

*Copper tripeptide-3* AHK-Cu	Peptides Bcl-2 Family	Others
Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect. Copper tripeptide-3 increases dermal cell proliferation and viability while increasing the deposition of collagen to renew the extracellular matrix. Copper tripeptide-3 stimulates the elongation of human hair follicles and proliferation of dermal papilla cells .

HY-P5250

*Palmitoyl tripeptide-5*	MMP	Others
Palmitoyl tripeptide-5 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P5242

Tripeptide-10 citrulline T10-C	Peptides	Others
Tripeptide-10 citrulline (T10-C) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P0278A

RGD Trifluoroacetate Maximum Cited Publications 8 Publications Verification	Integrin	Cancer
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.

HY-W016012

Glu-Glu H-Glu-Glu-OH; Glutamyl-glutamic acid	Amino Acid Derivatives	Others
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption .

HY-117483

Gly-Pro-Glu	iGluR	Neurological Disease
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC₅₀ value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

HY-P0047A

*Palmitoyl Tripeptide-1 hydrochloride*	Peptides	Others
Palmitoyl tripeptide-1 hydrochloride is a fatty acid modified polypeptide. Palmitoyl Tripeptide-1 has good wrinkle-removing effect .

HY-W111226

Fmoc-His(3-Me)-OH	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease .

HY-P3519

ACV Tripeptide	Drug Intermediate	Infection
ACV Tripeptide, a tripeptide, is the first dedicated intermediate in the biosynthetic pathway leading to the penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. ACV Tripeptide is is synthesized nonribosomally by the ACV synthetase (ACVS) enzyme, which is encoded by the 11 kb The pchAB gene encodes this enzyme. ACV Tripeptide can be used for the biosynthesis of β-lactam antibiotics .

HY-66018

*Palmitoyl tripeptide-5 diTFA*	Peptides	Others
Palmitoyl tripeptide-5 biTFA is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P4242

Ala-Gly-Ala H-Ala-Gly-Ala-OH	Peptides	Others
Ala-Gly-Ala is a prototype of a general tripeptide Xxx-Gly-Zzz. Except glycine and proline, there can be 18 possible amino acids for Xxx and another 18 amino acids for Zzz. Ala-Gly-Ala can be used as a model for up to 324 possible motifs of this kind of tripeptide .

HY-P4294

H-Gly-Pro-Gly-OH Gly-Pro-Gly	Amino Acid Derivatives	Others
H-Gly-Pro-Gly-OH is a tripeptide containing glycine and proline. H-Gly-Pro-Gly-OH can be used for the synthesis of other polypeptides, such as (Pro Gly Gly)_n .

HY-111173

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

HY-106263B

Tyroserleutide hydrochloride	PTEN PDK-1 MDM-2/p53 Apoptosis Akt	Cancer
Tyroserleutide hydrochloride is a tripeptide isolated from the degradation products of porcine spleen with antitumor activity. Tyroserleutide hydrochloride can upregulate the expression of the tumor suppressor gene PTEN and inhibit the activity of AKT and PDK1. Tyroserleutide hydrochloride inhibits tumor cell proliferation and MDM2 phosphorylation by inhibiting the PI3K/AKT pathway, and also upregulates P21, P27, P53, and induces mitochondrial damage and cell apoptosis .

HY-129724

α-MSH (11-13) ACTH-(11-13); Lys-Pro-Val; H-Lys-Pro-Val-OH	Melanocortin Receptor Bacterial NF-κB Apoptosis Interleukin Related	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections .

HY-P4209

Boc-GRR-AMC	Peptides	Others
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-P5226

*Palmitoyl tripeptide-8*	Peptides	Inflammation/Immunology
Palmitoyl tripeptide-8 s a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient .

HY-P4231

H-Gly-Ala-Hyp-OH Gly-Ala-Hyp	Peptides	Others
H-Gly-Ala-Hyp-OH is a collagen tripeptide fragment .

HY-P4381

γ-Glu-Gly-Gly	Peptides	Metabolic Disease
γ-Glu-Gly-Gly is a tripeptide that can be used as a peptide substrate to generate Glu .

HY-114424A

H-Ile-Pro-Pro-OH hydrochloride 1 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide , inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM . Antihypertensive tripeptides .

HY-P4286

H-Gly-Leu-Phe-OH	Peptides	Cancer
H-Gly-Leu-Phe-OH (GLF), an immunostimulatory tripeptide derived from α-lactalbumin, inhibits anticancer agent Etoposide-induced alopecia, epidermal thickening, and thinning of the adipocyte layer .

HY-P4383

H-Leu-Leu-Ala-OH	Peptides	Others
H-Leu-Leu-Ala-OH is a tripeptide composed of two L-leucine units joined to L-alanine by a peptide linkage. H-Leu-Leu-Ala-OH shows antioxidant activities .

HY-P11358

IRW	Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism	Inflammation/Immunology
IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation .

HY-P5252

*Diaminopropionoyl tripeptide-33*	Tyrosinase	Metabolic Disease
Diaminopropionoyl tripeptide-33isa bioactive peptide with protects skin cells from UVA-induced DNA damages and has been reported used as a cosmetic ingredient .

HY-W010777

Tripeptide YYY	Amino Acid Derivatives	Others
(S)-2-((S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoic acid is a tyrosine derivative .

HY-148337

Thr-Val-Leu	Peptides	Others
Thr-Val-Leu is a central nervous system tripeptide and reduces Thr-Val-Leu content in schizophrenic brain tissue .

HY-P4834

Acetyl-α-MSH (11-13)	Peptides	Inflammation/Immunology
Acetyl-α-MSH (11-13) is the acetylated C-terminal tripeptide of α-MSH with antipyretic and anti-inflammatory activities .

HY-P3888

Gly-Leu-Met-NH2	Neurokinin Receptor	Neurological Disease
Gly-Leu-Met-NH2 is a C-terminal tripeptide of Substance P (HY-P0201). Substance P is a neuropeptide .

HY-W480799

H-Gly-Gly-Tyr-OH Gly-Gly-Tyr	Biochemical Assay Reagents	Others
H-Gly-Gly-Tyr-OH is a tripeptide that plays an important role in various biochemical applications. H-Gly-Gly-Tyr-OH can be used in the fields of pharmaceuticals and biochemistry .

HY-114707

Threonyl-seryl-lysine	GnRH Receptor	Endocrinology
Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5 .

HY-P3534

EILDV (human, bovine, rat)	Peptides	Cancer
EILDV (human, bovine, rat) is an analogue of the active pentapeptide. EILDV (human, bovine, rat) has active tripeptide amino acid sequence LDV that is conserved in human, bovine, rat. EILDV (human, bovine, rat) can be used for the research of cell adhesion .

HY-P5037

Fmoc-Gly-Pro-Hyp-OH	Peptides	Others
Fmoc-Gly-Pro-Hyp-OH is a tripeptide that can be used in peptide synthesis .

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