2239-67-0
Chemical Structure
H-Gly-Pro-Hyp-OH
Synonym(s): Tripeptide 29
- CAS No.: 2239-67-0
- Formula:C12H19N3O5
- Molecular Weight:285.30
IUPAC Name: (2S,4R)-1-(glycyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxylic acid
InChIKey: SZEOBSAZWJLOGY-VGMNWLOBSA-N
SMILES: O=C(O)[C@H]1N(C([C@H]2N(C(CN)=O)CCC2)=O)C[C@H](O)C1
Biological Activity: H-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis[1][2][3][4].
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H-Gly-Pro-Hyp-OH | 99.48% | H-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis. | ||||||||||||||||||||
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- [1]. Yazaki M, et al. Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. J Agric Food Chem. 2017;65(11):2315-2322. [Content Brief]
- [2]. Yang D, et al. Effects of collagen hydrolysates on UV-induced photoaging mice: Gly-Pro-Hyp as a potent anti-photoaging peptide. Food Funct. 2024;15(6):3008-3022. Published 2024 Mar 18. [Content Brief]
- [3]. Lee HJ, et al. Orally administered collagen peptide protects against UVB-induced skin aging through the absorption of dipeptide forms, Gly-Pro and Pro-Hyp. Biosci Biotechnol Biochem. 2019;83(6):1146-1156. [Content Brief]
- [4]. Knight CG, et al. Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen. Cardiovasc Res. 1999;41(2):450-457. [Content Brief]
Keywords
