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Results for "

trypanosomes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) AMPK (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (1) Apolipoprotein (1) Bacterial (1) Biochemical Assay Reagents (1) Clathrin (1) DNA/RNA Synthesis (1) Fluorescent Dye (1) Fungal (1) Mitochondrial Metabolism (1) mRNA (1) NF-κB (1) p38 MAPK (1) Parasite (20) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Ser/Thr Protease (1) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (23) Inflammation/Immunology (5) Metabolic Disease (1)

By Targets:

5-HT Receptor (1)

AMPK (1)

Angiotensin Receptor (1)

Angiotensin-converting Enzyme (ACE) (3)

Antibiotic (1)

Apolipoprotein (1)

Bacterial (1)

Biochemical Assay Reagents (1)

Clathrin (1)

DNA/RNA Synthesis (1)

Fluorescent Dye (1)

Fungal (1)

Mitochondrial Metabolism (1)

mRNA (1)

NF-κB (1)

p38 MAPK (1)

Parasite (20)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

Ser/Thr Protease (1)

STAT (1)

TNF Receptor (1)

By Research Areas:

Cancer (1)

Cardiovascular Disease (1)

Infection (23)

Inflammation/Immunology (5)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12404

Diminazene aceturate 10+ Cited Publications Diminazene diaceturate	Parasite Angiotensin-converting Enzyme (ACE)	Infection Inflammation/Immunology
Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .

HY-N0397

Harpagide	Parasite	Infection Inflammation/Immunology
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-169932

APOL1-IN-2	Apolipoprotein	Infection
APOL1-IN-2 (Compound 467) is the inhibitor for Apolipoprotein 1 (APOL1). APOL1-IN-2 reduces the APOL1 G2/G1 induced cell death in HEK293 with EC₅₀ of 4.74 nM and 14.3 nM. APOL1-IN-2 reduces the APOL1 G2/G1/G0 induced death of trypanosomes with EC₅₀ of 2.24, 6.03 and 3.72 nM, respectively .

HY-155531

PEX5-PEX14 PPI-IN-2	Biochemical Assay Reagents	Infection
PEX5-PEX14 PPI-IN-2 (compound 12) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor. PEX5-PEX14 PPI-IN-2 inhibits PEX14-PEX5 PPI with EC₅₀ values of 5 and 17 µM in T. b. brucei and HepG2 cells, respectively. PEX5-PEX14 PPI-IN-2 can be used in the research of diseases related to trypanosome infection .

HY-121405

Malonomicin Antibiotic K16	Antibiotic Parasite	Infection
Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and *anti-trypanosome* activities. Malonomicin also shows anti-trypanosome activity in vivo .

HY-W342283

Diminazene	Parasite Angiotensin-converting Enzyme (ACE) Angiotensin Receptor p38 MAPK STAT NF-κB TNF Receptor 5-HT Receptor	Cardiovascular Disease Infection Inflammation/Immunology
Diminazene is an antiparasitic agent widely used to treat parasitic diseases caused by hemoparasites (such as trypanosomes and babesia). Diminazene acts as an ACE2 activator and exerts cardiovascular protective effects by activating the ACE2/Ang-(1-7)/Mas receptor axis. By regulating gut microbiota-tryptophan metabolism, Diminazene inhibits the activation of core inflammatory signaling pathways including MAPK, STAT and NF-κB, increases central 5-HT levels, and suppresses splenic TNF-α production, thereby alleviating systemic inflammation .

HY-118996B

Isometamidium chloride hydrochloride	Parasite	Infection
Isometamidium chloride hydrochloride is an antiprotozoal agent, that exhibits activity against trypanosome. Isometamidium chloride hydrochloride can be used in research of african sleeping sickness .

HY-118996A

Isometamidium chloride	Parasite	Infection
Isometamidium chloride is an antiprotozoal agent, that exhibits activity against trypanosome. Isometamidium chloride can be used in research of african sleeping sickness .

HY-112905

AN11736	Parasite mRNA	Infection
AN11736 is a CPSF3 inhibitor. AN11736 exerts a potent anti-trypsin effect by specifically inhibiting the activity of the trypanosome CPSF3 endonuclease, disrupting the mRNA maturation process. AN11736 exhibits IC₅₀s against T. congolense and T. vivax of 0.14 and 1.3 nM, respectively. AN11736 exhibits strong anti-trypsin activity in mouse and cattle models .

HY-149985

Antitrypanosomal agent 12	Parasite	Infection
Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI₅₀) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597) .

HY-N1985

Acetylastragaloside I	Parasite	Infection
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and *T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome* infection .

HY-178064

Antiparasitic agent-29	Parasite Mitochondrial Metabolism	Infection
Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC₅₀ of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research .

HY-176253

Antitrypanosomal agent 26	Parasite	Infection
Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC₅₀ value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .

HY-P10795

NK-2 Antibiotic NK 2	Parasite Bacterial Fungal	Infection
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .

HY-N0397R

Harpagide (Standard)	Reference Standards Parasite	Infection Inflammation/Immunology
Harpagide (Standard) is the analytical standard of Harpagide. This product is intended for research and analytical applications. Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC₅₀ of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-12404R

Diminazene aceturate (Standard) Diminazene diaceturate (Standard)	Reference Standards Parasite Angiotensin-converting Enzyme (ACE)	Infection Inflammation/Immunology
Diminazene (aceturate) (Standard) is the analytical standard of Diminazene (aceturate). This product is intended for research and analytical applications. Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .

HY-114734

Didesmethylpromazine	Parasite	Infection
Didesmethylpromazine (Compound 18) is a trypanothione reductase inhibitor with an I₅₀of 1412 μM against T. cruzi trypanothione reductase. Didesmethylpromazine can be used in the research of trypanosome and leishmania infections .

HY-178326

NEU-5123	Parasite	Infection
NEU-5123 is a human kinase inhibitor with potent inhibitory activity to several kinases. NEU-5123 is a Trypanosome proliferation inhibitor. NEU-5123 can be used for the research of infection .

HY-180418

Homidium chloride	Parasite	Infection
Homidium chloride is a potent antiparasitic agent exhibiting activity against Trypanosoma rhodesiense and Trypanosoma congolense. Homidium chloride can reduce parasitaemia in murine models of infection. Homidium chloride can be used for trypanosomiasis research .

HY-125188

NEU-4438	Parasite DNA/RNA Synthesis AMPK Clathrin	Infection
NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model .

HY-183747

Antitrypanosomal agent 32	Parasite	Infection
Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of *trypanosome* infection .

HY-180158

Antitrypanosomal agent 28	Parasite Reactive Oxygen Species (ROS)	Infection Cancer
Antitrypanosomal agent 28 (Compound 2a) is a trypanocidal agent. Antitrypanosomal agent 28 effectively inhibits Trypanosoma cruzi by inducing the generation of ROS and mitochondrial damage, with an IC₅₀ of 49.4 μM. Antitrypanosomal agent 28 exhibits broad-spectrum anti-tumor activity against various tumor cell lines, especially being sensitive to leukemia, colon cancer, and breast cancer. Antitrypanosomal agent 28 can be used for research on anti-cancer and anti-trypanosome activities .

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

Cat. No.	Product Name	Target	Research Area

HY-P10795

NK-2 Antibiotic NK 2	Parasite Bacterial Fungal	Infection
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

Harpagide	Iridoids Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Parasite
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

Acetylastragaloside I	Triterpenes Structural Classification Tetracyclic Triterpenoids Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Parasite
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and *T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome* infection .

Harpagide (Standard)	Iridoids Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Source Classification	Reference Standards Parasite
Harpagide (Standard) is the analytical standard of Harpagide. This product is intended for research and analytical applications. Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC₅₀ of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

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