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Cat. No.: HY-184074

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Enfiborole

Enfiborole is an oxaborolane ester inhibitor with trypanocidal activity against parasites. Enfiborole displays IC₅₀ values ≤ 20 nM against Trypanosoma brucei and Trypanosoma cruzi, and its IC₅₀ against replicating trypanosomes ranges from 21 to 999 nM. Enfiborole inhibits the growth of Trypanosoma brucei, suppresses hypoxanthine incorporation in replicating trypanosomes, and inhibits the growth of Trypanosoma cruzi amastigotes. Enfiborole can be used in studies related to trypanosome infections.

For research use only. We do not sell to patients.

CAS No.: 2152662-88-7
Formula: C₂₁H₂₂BF₃N₂O₅
Molecular Weight:450.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Enfiborole Chemical Structure

CAS No.: 2152662-88-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Trypanosoma

All Parasite Isoforms :

In Vitro

Enfiborole (6-168) potently inhibits Trypanosoma congolense growth and Trypanosoma cruzi amastigote growth with IC₅₀ values ≤ 20 nM, and inhibits Trypanosoma vivax hypoxanthine incorporation with an IC₅₀ in the range of 21-999 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2152662-88-7
Molecular Weight 450.22
Formula C₂₁H₂₂BF₃N₂O₅
SMILES

CC1=C2C(COB2O)=CC=C1C(N[C@@H](C(C)C)C(OCC3=CN=C(C(F)(F)F)C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Akama T, et al. Oxaborole esters and uses thereof. WO2017195069A1. WIPO; 2017 Nov 16.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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