2. Anti-infection
  3. Parasite
  4. Enfiborole

Enfiborole is an oxaborolane ester inhibitor with trypanocidal activity against parasites. Enfiborole displays IC50 values ≤ 20 nM against Trypanosoma brucei and Trypanosoma cruzi, and its IC50 against replicating trypanosomes ranges from 21 to 999 nM. Enfiborole inhibits the growth of Trypanosoma brucei, suppresses hypoxanthine incorporation in replicating trypanosomes, and inhibits the growth of Trypanosoma cruzi amastigotes. Enfiborole can be used in studies related to trypanosome infections.

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Enfiborole

Enfiborole Chemical Structure

CAS No. : 2152662-88-7

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Enfiborole Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Enfiborole is an oxaborolane ester inhibitor with trypanocidal activity against parasites. Enfiborole displays IC50 values ≤ 20 nM against Trypanosoma brucei and Trypanosoma cruzi, and its IC50 against replicating trypanosomes ranges from 21 to 999 nM. Enfiborole inhibits the growth of Trypanosoma brucei, suppresses hypoxanthine incorporation in replicating trypanosomes, and inhibits the growth of Trypanosoma cruzi amastigotes. Enfiborole can be used in studies related to trypanosome infections[1].

IC50 & Target[1]

Trypanosoma

 

In Vitro

Enfiborole (6-168) potently inhibits Trypanosoma congolense growth and Trypanosoma cruzi amastigote growth with IC50 values ≤ 20 nM, and inhibits Trypanosoma vivax hypoxanthine incorporation with an IC50 in the range of 21-999 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enfiborole Related Antibodies
Molecular Weight

450.22

Formula

C21H22BF3N2O5
CAS No.
SMILES

CC1=C2C(COB2O)=CC=C1C(N[C@@H](C(C)C)C(OCC3=CN=C(C(F)(F)F)C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Enfiborole Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enfiborole2152662-88-7ParasiteTrypanosoma cruzi amastigoteschagas diseasehypoxanthine incorporationTrypanosoma congolenseTrypanosoma vivaxafrican animal trypanosomosisTrypanosoma cruziInhibitorinhibitorinhibit

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