2. Apoptosis
  3. Apoptosis
  4. Sec61-IN-4

Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC50: 0.04 nM in U87-MG cells).

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Sec61-IN-4

Sec61-IN-4 Chemical Structure

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Sec61-IN-4 Related Antibodies

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Description

Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC50: 0.04 nM in U87-MG cells)[1].

Cellular Effect
Cell Line Type Value Description References
A549 CC50
1.3 nM
Compound: 16b
Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
[PMID: 37849553]
HCT-116 CC50
3.4 nM
Compound: 16b
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
[PMID: 37849553]
NHDF CC50
3.9 nM
Compound: 16b
Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
[PMID: 37849553]
U-87MG ATCC CC50
2.2 nM
Compound: 16b
Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
[PMID: 37849553]
U-87MG ATCC IC50
0.04 nM
Compound: 16b
Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
[PMID: 37849553]
Masse moléculaire

1286.64

Formule

C65H111N11O15
SMILES

CN(C)[C@H](C(O[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(N(C)[C@H](C(N(C)[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@H](C(N[C@H](C1=O)CC2=CC=C(C=C2)OC)=O)CC(C)C)=O)C)=O)=O)COC)=O)[C@H](NC([C@@H](C)N1C)=O)C)=O)=O)COC)C)=O)C(C)C)=O)C(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Sec61-IN-4 Related Classifications

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sec61-IN-4ApoptosisSec61U87-MG cellInhibitorinhibitorinhibit

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HY-156349
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