Ac-ATS010-KE
Ac-ATS010-KE is a selective polypeptide inhibitor of caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase-3-targeted molecular probes.
For research use only. We do not sell to patients.
- CAS No.: 2379342-67-1
- Formula: C43H41F5N6O12S
- Molecular Weight:960.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Caspase Isoforms
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Biological Activity
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Caspase-3 |
Ac-ATS010-KE potently inhibits purified recombinant caspase-3 and exhibits high selectivity over caspase-6, caspase-7, caspase-8, caspase-9, and caspase-10[1].
Ac-ATS010-KE protects Jurkat cells from MegaFasL-induced apoptosis, with non-methylated Ac-ATS010-KE showing superior performance compared to its per-methylated counterpart[1].
Ac-ATS010-KE (25 µM; 1 hour) reduces [18F]MICA-316 uptake in STS-treated caspase-3-positive HeLa cells, demonstrating competitive binding to caspase-3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2379342-67-1
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Molecular Weight 960.88
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Formula C43H41F5N6O12S
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Sequence
Ac-Pal-Asp-{Phe(F5)}-Phe-Asp-KE
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Sequence Shortening
Ac-{Pal}-D-{Phe(F5)}-FD-KE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)