tau-0N4R-IN-1
tau-0N4R-IN-1 (Compound 6T) is an BBB-penetrable inhibitor of tau 0N4R oligomerization. tau-0N4R-IN-1 effectively inhibits the fibrosis of tau 0N4R, 2N3R, and 2N4R, exhibits an anti-seeding effect on tau in vitro, reduces the oligomerization of α-syn dose-dependently, and prevents formation of α-syn inclusions. tau-0N4R-IN-1 is stable in mouse microsomes and reduces Aβ plaques in brain tissues from AD patients. tau-0N4R-IN-1 has good pharmacokinetic properties in mice.
For research use only. We do not sell to patients.
- CAS No.: 2200453-71-8
- Formula: C16H19N3S
- Molecular Weight:285.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All α-synuclein Isoforms
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Biological Activity
Description
IC50 & Target
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α-synuclein Aggregation |
In Vitro
tau-0N4R-IN-1 (12.5-100 μM, 2500 min) inhibits the formation of α-syn oligomers with a delayed lag time (time to increase fluorescence intensity) at a concentration of 100 μM in the ThT assay, and between 12.5 and 50 μM in the PICUP assay[1].
tau-0N4R-IN-1 (100 μM) causes a decrease in tau 2N3R and 2N4R (10 μM) protofibrils[1].
tau-0N4R-IN-1 (100 and 200 μM) slightly reduces oligomerization of tau 0N4R[1].
tau-0N4R-IN-1 (50 μM, 5 days) reduces Aβ plaques isolated from AD patients[1].
tau-0N4R-IN-1 (40 μM, 96 h) prevents the formation of α-syn inclusions in M17D neuroblastoma cells expressing the fusion protein αS-3K::YFP [1].
tau-0N4R-IN-1 (5-20 μM, 48 h) has anti-inoculation effects in TauRD P301S FRET biosensor cells[1].
tau-0N4R-IN-1 (3 μM) is stable in mouse microsomes with 74% remaining at 30 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Chemical Information
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CAS No. 2200453-71-8
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Molecular Weight 285.41
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Formula C16H19N3S
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SMILES
S=C(N(C)C1=CC=CC=C1)NC2=CC=C(N(C)C)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
tau-0N4R-IN-1 Related Classifications
HY-159941 Related Classifications
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