tau-0N4R-IN-1
tau-0N4R-IN-1 (Compound 6T) is an BBB-penetrable inhibitor of tau 0N4R oligomerization. tau-0N4R-IN-1 effectively inhibits the fibrosis of tau 0N4R, 2N3R, and 2N4R, exhibits an anti-seeding effect on tau in vitro, reduces the oligomerization of α-syn dose-dependently, and prevents formation of α-syn inclusions. tau-0N4R-IN-1 is stable in mouse microsomes and reduces Aβ plaques in brain tissues from AD patients. tau-0N4R-IN-1 has good pharmacokinetic properties in mice.
For research use only. We do not sell to patients.
- CAS No.: 2200453-71-8
- Formula: C16H19N3S
- Molecular Weight:285.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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All α-synuclein Isoforms
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Biological Activity
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α-synuclein Aggregation |
tau-0N4R-IN-1 (12.5-100 μM, 2500 min) inhibits the formation of α-syn oligomers with a delayed lag time (time to increase fluorescence intensity) at a concentration of 100 μM in the ThT assay, and between 12.5 and 50 μM in the PICUP assay[1].
tau-0N4R-IN-1 (100 μM) causes a decrease in tau 2N3R and 2N4R (10 μM) protofibrils[1].
tau-0N4R-IN-1 (100 and 200 μM) slightly reduces oligomerization of tau 0N4R[1].
tau-0N4R-IN-1 (50 μM, 5 days) reduces Aβ plaques isolated from AD patients[1].
tau-0N4R-IN-1 (40 μM, 96 h) prevents the formation of α-syn inclusions in M17D neuroblastoma cells expressing the fusion protein αS-3K::YFP [1].
tau-0N4R-IN-1 (5-20 μM, 48 h) has anti-inoculation effects in TauRD P301S FRET biosensor cells[1].
tau-0N4R-IN-1 (3 μM) is stable in mouse microsomes with 74% remaining at 30 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2200453-71-8
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Molecular Weight 285.41
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Formula C16H19N3S
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SMILES
S=C(N(C)C1=CC=CC=C1)NC2=CC=C(N(C)C)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
tau-0N4R-IN-1 Related Classifications
HY-159941 Related Classifications
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