Teleocidin A1
Teleocidin A1 (Lyngbyatoxin A) is a PKC activator with a Ki value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning.
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- CAS. Nr.: 70497-14-2
- Formel: C27H39N3O2
- Molecular Weight:437.62
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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PKCδ-C1B 0.11 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
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| L1210 | IC50 |
8.1 μM
Compound: 25
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Cytotoxicity against mouse L1210 cells assessed as inhibition of cell growth
Cytotoxicity against mouse L1210 cells assessed as inhibition of cell growth
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[PMID: 32652435] |
Teleocidin A1 (incubated for 48 h) potently inhibits the proliferation of HeLa cervical cancer cells, with an IC50 value of 9.2 nM[1].
Teleocidin A1 (incubated for 24 h) inhibits the proliferation of L1210 mouse leukemia cells, with an IC50 value of 8.1 μM[2].
Teleocidin A1 binds to the PKCδ-C1B peptide segment with high affinity, with a Ki value of 0.11 nM for the inhibition of [3H]PDBu, a result that confirms the aforementioned binding characteristics[2].
Lyngbyatoxin A (26 μg/cm2; 1-48 h) rapidly penetrates the abdominal skin of ex vivo male Hartley guinea pigs, reaching a peak of 23% of the administered dose within 1 hour, with no significant changes in the penetration amount at subsequent time points[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Palaemon paucidens (average weight 0.5 g)[2]
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Dosage:0.6 mg/kg
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Administration:injection
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Result:Reached an LD33 value of 0.6 mg/kg.
Was approximately 150-times more potent than compound 1 (LD33 89 mg/kg).
Was 40-times more potent than compound 2 (LD33 25 mg/kg).
Chemical Information
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CAS. Nr. 70497-14-2
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Molecular Weight 437.62
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Formel C27H39N3O2
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SMILES
C/C(C)=C\CC[C@@](C)(C1=C2C3=C(C=C1)N([C@H](C(N[C@@H](CC3=CN2)CO)=O)C(C)C)C)C=C
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Synonyms
Lyngbyatoxin A
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Structure Classification
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Initial Source
Streptomyces
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Youssef DT, et al. 2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res. 2015;29(8):703-9. [Content Brief]
[2]. Jiang W, et al. Two new lyngbyatoxin derivatives from the Cyanobacterium, Moorea producens. Mar Drugs. 2014;12(12):5788-5800. Published 2014 Dec 1. [Content Brief]
[3]. Stafford RG, et al. Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A). Food Chem Toxicol. 1992;30(9):795-801. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Teleocidin A1 Related Classifications
HY-118834 Related Classifications
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- Teleocidin A1
- 70497-14-2
- Lyngbyatoxin A
- Teleocidin A 1
- Teleocidin A-1
- PKC
- Streptomyces mediocidicus
- Palaemon paucidens
- protein kinase C
- PKCδ-C1B peptide
- human abdominal cadaver skin
- L1210 mouse leukemia cells
- male Hartley guinea pig ventral skin
- cervical cancer
- PKC C1 domains
- HeLa cervical cancer cells
- Inhibitor
- inhibitor
- inhibit