2. Epigenetics TGF-beta/Smad
  3. PKC
  4. Teleocidin A1

Teleocidin A1 (Lyngbyatoxin A) is a PKC activator with a Ki value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning.

For research use only. We do not sell to patients.

Teleocidin A1

Teleocidin A1 Chemical Structure

CAS No. : 70497-14-2

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Based on 1 publication(s) in Google Scholar

Teleocidin A1 Related Antibodies

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Description

Teleocidin A1 (Lyngbyatoxin A) is a PKC activator with a Ki value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning[1][2][3][4].

IC50 & Target[2]

PKCδ-C1B

0.11 nM (Ki)

Cellular Effect
Cell Line Type Value Description References
L1210 IC50
8.1 μM
Compound: 25
Cytotoxicity against mouse L1210 cells assessed as inhibition of cell growth
Cytotoxicity against mouse L1210 cells assessed as inhibition of cell growth
[PMID: 32652435]
In Vitro

Teleocidin A1 (incubated for 48 h) potently inhibits the proliferation of HeLa cervical cancer cells, with an IC50 value of 9.2 nM[1].
Teleocidin A1 (incubated for 24 h) inhibits the proliferation of L1210 mouse leukemia cells, with an IC50 value of 8.1 μM[2].
Teleocidin A1 binds to the PKCδ-C1B peptide segment with high affinity, with a Ki value of 0.11 nM for the inhibition of [3H]PDBu, a result that confirms the aforementioned binding characteristics[2].
Lyngbyatoxin A (26 μg/cm2; 1-48 h) rapidly penetrates the abdominal skin of ex vivo male Hartley guinea pigs, reaching a peak of 23% of the administered dose within 1 hour, with no significant changes in the penetration amount at subsequent time points[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Teleocidin A1 Related Antibodies
In Vivo

Teleocidin A1 (administered via injection) exhibits potent lethal activity against Palaemon paucidens (slender prawn), with an LD33 value of 0.6 mg/kg, which is significantly higher than the activity of the tested derivatives[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Palaemon paucidens (average weight 0.5 g)[2]
Dosage: 0.6 mg/kg
Administration: injection
Result: Reached an LD33 value of 0.6 mg/kg.
Was approximately 150-times more potent than compound 1 (LD33 89 mg/kg).
Was 40-times more potent than compound 2 (LD33 25 mg/kg).
Molecular Weight

437.62

Formula

C27H39N3O2
CAS No.
SMILES

C/C(C)=C\CC[C@@](C)(C1=C2C3=C(C=C1)N([C@H](C(N[C@@H](CC3=CN2)CO)=O)C(C)C)C)C=C
Structure Classification
Initial Source

Streptomyces
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Teleocidin A1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teleocidin A170497-14-2Lyngbyatoxin ATeleocidin A 1Teleocidin A-1PKCProtein kinase CStreptomyces mediocidicusPalaemon paucidensprotein kinase CPKCδ-C1B peptidehuman abdominal cadaver skinL1210 mouse leukemia cellsmale Hartley guinea pig ventral skincervical cancerPKC C1 domainsHeLa cervical cancer cellsInhibitorinhibitorinhibit

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