1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. TRPC5-IN-4

TRPC5-IN-4 

Cat. No.: HY-144429
Handling Instructions

TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD).

For research use only. We do not sell to patients.

TRPC5-IN-4 Chemical Structure

TRPC5-IN-4 Chemical Structure

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Description

TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD)[1].

IC50 & Target[1]

TRPC5

14.07 nM (IC50)

TRPC4

65 nM (IC50)

In Vitro

TRPC5-IN-4 (compound 16 g) (0.003-3 μM; 0-1000 seconds) significantly changes intracellular Ca2+ concentration in TRPC4- and TRPC5-HEK293 cells in a dose-dependent manner, and shows very weak inhibitory activity on the TRPC3 channel, no inhibitory effect on TRPC6 and TRPC7 channels[1].
TRPC5-IN-4 (1 and 10 μM; 24 hours) does not reduce the liver and kidney cells viability[1].
TRPC5-IN-4 (0.1, 0.3, 1, 3 μM; 30 minutes) concentration-dependently reduces the PS-induced podocyte rearrangement in MPC5 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: Primary cultured hepatocytes and MPC5 cells[1]
Concentration: 1 and 10 μM
Incubation Time: 24 hours
Result: Did not reduce the cell viability, suggesting that TRPC5-IN-4 was unlikely to damage the cellular component of liver and kidney.
Molecular Weight

442.75

Formula

C18H11ClF4N4O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
TRPC5-IN-4
Cat. No.:
HY-144429
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