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Cat. No.: HY-145821

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Tubulin inhibitor 15

Tubulin inhibitor 15 is a potent tubulin inhibitor. Tubulin inhibitor 15 shows antiproliferative activity. Tubulin inhibitor 15 shows cytotoxicity in HepG2 cells.

For research use only. We do not sell to patients.

CAS No.: 2767446-36-4
Formula: C₁₆H₁₂FNO₂
Molecular Weight:269.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tubulin inhibitor 15 Chemical Structure

CAS No.: 2767446-36-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tubulin inhibitor 15 is a potent tubulin inhibitor. Tubulin inhibitor 15 shows antiproliferative activity. Tubulin inhibitor 15 shows cytotoxicity in HepG2 cells^[1].

In Vitro

Tubulin inhibitor 15 (compound 6) (0-25 µM, 24 h followed by a 72 h compound-free incubation period) shows antiproliferative activity with IC₅₀s of 1.60, 0.22, 1.40, 0.68, 0.47, 0.21, >25 µM for MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116, THLE-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116 cells
Concentration:

0-50 µM
Incubation Time:

96 h
Result:

Showed antiproliferative activity with IC₅₀s of 0.68, 0.21, 3.03, 0.60, 0.38, 0.19 µM for MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116 cells, respectively.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2 cells
Concentration:

0.5, 1 µM
Incubation Time:

14 days
Result:

Showed no colonies were apparent when cells were treated with 0.5 or 1 µM.

Chemical Information

CAS No. 2767446-36-4
Molecular Weight 269.27
Formula C₁₆H₁₂FNO₂
SMILES

O=C1C2=CC(F)=CC=C2C=C(N1)C3=CC=CC(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Elhemely MA,et al. SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules. J Med Chem. 2022 Mar 24;65(6):4783-4797. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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