Tubulin inhibitor 15

Cat. No.: HY-145821: Data Sheet Handling Instructions
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Tubulin inhibitor 15 is a potent tubulin inhibitor. Tubulin inhibitor 15 shows antiproliferative activity. Tubulin inhibitor 15 shows cytotoxicity in HepG2 cells.

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Tubulin inhibitor 15 화학구조

CAS No. : 2767446-36-4

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Tubulin inhibitor 15 is a potent tubulin inhibitor. Tubulin inhibitor 15 shows antiproliferative activity. Tubulin inhibitor 15 shows cytotoxicity in HepG2 cells^[1].

In Vitro

Tubulin inhibitor 15 (compound 6) (0-25 µM, 24 h followed by a 72 h compound-free incubation period) shows antiproliferative activity with IC₅₀s of 1.60, 0.22, 1.40, 0.68, 0.47, 0.21, >25 µM for MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116, THLE-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116 cells
Concentration:	0-50 µM
Incubation Time:	96 h
Result:	Showed antiproliferative activity with IC₅₀s of 0.68, 0.21, 3.03, 0.60, 0.38, 0.19 µM for MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116 cells, respectively.

Cell Cytotoxicity Assay^[1]

Cell Line:	HepG2 cells
Concentration:	0.5, 1 µM
Incubation Time:	14 days
Result:	Showed no colonies were apparent when cells were treated with 0.5 or 1 µM.

분자량

269.27

화학식

C₁₆H₁₂FNO₂

CAS No.

2767446-36-4

SMILES

O=C1C2=CC(F)=CC=C2C=C(N1)C3=CC=CC(OC)=C3

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Elhemely MA,et al. SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules. J Med Chem. 2022 Mar 24;65(6):4783-4797. [Content Brief]