country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-160854

Copy Link Print Information

Tubulin inhibitor 43

Tubulin inhibitor 43 (Compound 29) has significant antitumor activity. Tubulin inhibitor 43 inhibits the proliferation and growth of cancer cells by inhibiting the activity of β-microtubulin, and finally induces apoptosis.

For research use only. We do not sell to patients.

CAS No.: 1541208-02-9
Formula: C₂₀H₂₁NO₆
Molecular Weight:371.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tubulin inhibitor 43 Chemical Structure

CAS No.: 1541208-02-9

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.115 μM Compound: 8	Growth inhibition of human A2780 cells Growth inhibition of human A2780 cells	[PMID: 27805821]
A549	IC₅₀	0.128 μM Compound: 1a	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 37563016]
BE(2)-C	IC₅₀	0.186 μM Compound: 1a	Antiproliferative activity against human BE2C cells incubated for 48 hrs by MTT assay Antiproliferative activity against human BE2C cells incubated for 48 hrs by MTT assay	[PMID: 37563016]
HCT-116	IC₅₀	0.234 μM Compound: 1a	Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay	[PMID: 37563016]
HeLa	IC₅₀	0.243 μM Compound: 8	Growth inhibition of human HeLa cells Growth inhibition of human HeLa cells	[PMID: 27805821]
MDA-MB-231	IC₅₀	0.308 μM Compound: 8	Growth inhibition of human MDA-MB-231 cells Growth inhibition of human MDA-MB-231 cells	[PMID: 27805821]
SK-OV-3	IC₅₀	0.114 μM Compound: 8	Growth inhibition of human SK-OV-3 cells Growth inhibition of human SK-OV-3 cells	[PMID: 27805821]
U-87MG ATCC	IC₅₀	0.143 μM Compound: 1a	Antiproliferative activity against human U-87 MG cells incubated for 48 hrs by MTT assay Antiproliferative activity against human U-87 MG cells incubated for 48 hrs by MTT assay	[PMID: 37563016]

Chemical Information

CAS No. 1541208-02-9
Molecular Weight 371.38
Formula C₂₀H₂₁NO₆
SMILES

O=C1N(C2=CC(OC)=C(C(OC)=C2)OC)[C@@H](C3=CC(O)=C(C=C3)OC)C1=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou P, et al.Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents. Eur J Med Chem. 2018 Jan 20;144:817-842. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote