2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin inhibitor 43

Tubulin inhibitor 43 (Compound 29) has significant antitumor activity. Tubulin inhibitor 43 inhibits the proliferation and growth of cancer cells by inhibiting the activity of β-microtubulin, and finally induces apoptosis.

For research use only. We do not sell to patients.

Tubulin inhibitor 43

Tubulin inhibitor 43 Chemical Structure

CAS No. : 1541208-02-9

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Tubulin inhibitor 43 Related Antibodies

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Description

Tubulin inhibitor 43 (Compound 29) has significant antitumor activity. Tubulin inhibitor 43 inhibits the proliferation and growth of cancer cells by inhibiting the activity of β-microtubulin, and finally induces apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.115 μM
Compound: 8
Growth inhibition of human A2780 cells
Growth inhibition of human A2780 cells
[PMID: 27805821]
A549 IC50
0.128 μM
Compound: 1a
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
BE(2)-C IC50
0.186 μM
Compound: 1a
Antiproliferative activity against human BE2C cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human BE2C cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
HCT-116 IC50
0.234 μM
Compound: 1a
Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
HeLa IC50
0.243 μM
Compound: 8
Growth inhibition of human HeLa cells
Growth inhibition of human HeLa cells
[PMID: 27805821]
MDA-MB-231 IC50
0.308 μM
Compound: 8
Growth inhibition of human MDA-MB-231 cells
Growth inhibition of human MDA-MB-231 cells
[PMID: 27805821]
SK-OV-3 IC50
0.114 μM
Compound: 8
Growth inhibition of human SK-OV-3 cells
Growth inhibition of human SK-OV-3 cells
[PMID: 27805821]
U-87MG ATCC IC50
0.143 μM
Compound: 1a
Antiproliferative activity against human U-87 MG cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human U-87 MG cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
Molecular Weight

371.38

Formula

C20H21NO6
CAS No.
SMILES

O=C1N(C2=CC(OC)=C(C(OC)=C2)OC)[C@@H](C3=CC(O)=C(C=C3)OC)C1=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin inhibitor 43 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 431541208-02-9Tubulin inhibitor43Tubulin inhibitor-43Microtubule/TubulinApoptosisAnti-proliferativeAngiogenesis inhibitionCell cycle arrestInhibitorinhibitorinhibit

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