Tubulin polymerization-IN-64
Tubulin polymerization-IN-64 (Compound 8a) is an inhibitor for tubulin polymerization by occupying the colchicine binding site of tubulin, with IC50 of 6.9 μM. Tubulin polymerization-IN-64 inhibits proliferations of cancer cells A549, HeLa, HCT116 and HT-29, with IC50s of 2.42, 10.33, 6.28, 5.33 μM, respectively. Tubulin polymerization-IN-64 arrests cell cycle at G2/M phase, induces apoptosis in A549.
For research use only. We do not sell to patients.
- Formula: C25H25NO6
- Molecular Weight:435.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 6.9 μM (tubulin polymerization)
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.42 μM
Compound: 8a
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 38806101] |
| HCT-116 | IC50 |
6.28 μM
Compound: 8a
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 38806101] |
| HEK293 | IC50 |
>100 μM
Compound: 8a
|
Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 38806101] |
| HeLa | IC50 |
10.33 μM
Compound: 8a
|
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 38806101] |
| HT-29 | IC50 |
5.33 μM
Compound: 8a
|
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
|
[PMID: 38806101] |
Chemical Information
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Molecular Weight 435.47
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Formula C25H25NO6
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SMILES
O=C(/C(C1=CC(OC)=C(C(OC)=C1)OC)=C/C2=CC=C(C(O)=C2)OC)NC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)