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Cat. No.: HY-184059

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Tyrphostin AG 537

Tyrphostin AG 537 is a dynamin I GTPase inhibitor with an IC₅₀ of 1.7 μM. Tyrphostin AG 537 inhibits phospholipid-stimulated GTPase activity without competing for the GTP domain or PH domain of dynamin I. Tyrphostin AG 537 inhibits spermidine-induced autoactivation of pro-plasma hyaluronan-binding protein (pro-PHBP) with an IC₅₀ of 0.018 μM. Tyrphostin AG 537 can be used in inflammation-related research.

For research use only. We do not sell to patients.

CAS No.: 140674-77-7
Formula: C₂₃H₂₀N₄O₆
Molecular Weight:448.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tyrphostin AG 537 Chemical Structure

CAS No.: 140674-77-7

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Tyrphostin AG 537 (compound 1) potently inhibits phospholipid-stimulated GTPase activity of purified sheep brain dynamin I with an IC₅₀ of 1.7 μM, while linker-modified analogues lack inhibitory activity at concentrations up to 500 μM^[1].
Tyrphostin AG 537 (compound 13) potently inhibits spermidine-induced autoactivation of human plasma-derived pro-PHBP with an IC₅₀ of 0.018 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 140674-77-7
Molecular Weight 448.43
Formula C₂₃H₂₀N₄O₆
SMILES

OC(C=C1/C=C(C#N)/C(NCCCNC(/C(C#N)=C/C2=CC(O)=C(C=C2)O)=O)=O)=C(C=C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Odell LR, et al. Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase. ChemMedChem. 2009 Jul;4(7):1182-8. [Content Brief]

[2]. Yamamoto E, et al. Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor VII activating protease) autoactivation. Bioscience, biotechnology, and biochemistry. 2011;75(10):2070-2. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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