2. GPCR/G Protein Immunology/Inflammation
  3. Protease Activated Receptor (PAR) P-selectin
  4. VU0652925

VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC50 values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation.

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VU0652925

VU0652925 Estructura química

No. CAS : 1476847-58-1

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VU0652925 Related Antibodies

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PAR1 PAR2 PAR4

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Descripciòn

VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC50 values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation[1].

Cellular Effect
Cell Line Type Value Description References
Platelet IC50
4.7 nM
Compound: 18
Antiplatelet activity in human platelet-rich plasma assessed as inhibition of gamma thrombin induced platelet aggregation preincubated for 5 mins followed by gamma thrombin addition and measured upto 15 mins by plate reader assay
Antiplatelet activity in human platelet-rich plasma assessed as inhibition of gamma thrombin induced platelet aggregation preincubated for 5 mins followed by gamma thrombin addition and measured upto 15 mins by plate reader assay
[PMID: 35729784]
Peso molecular

490.55

Fòrmula

C24H18N4O4S2
No. CAS
SMILES

COC1=NN2C(S1)=NC(C3=CC4=C(C=C(C=C4OCC5=CSC(C6=CC=CC=C6)=N5)OC)O3)=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Pureza y Documentación
Referencias
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VU0652925 Related Classifications

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Keywords:

VU06529251476847-58-1VU 0652925VU-0652925Protease Activated Receptor (PAR)P-selectinThrombin receptorsCD62PAR4GPIIbIIIaInhibitorinhibitorinhibit

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Nombre del producto:
VU0652925
Cat. No.:
HY-119158
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