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Cat. No.: HY-150560

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α-Glucosidase-IN-11

α-Glucosidase-IN-11 is a highly permeable competitive α-glucosidase inhibitor with the IC₅₀ value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels.

For research use only. We do not sell to patients.

CAS No.: 2411744-76-6
Formula: C₂₃H₂₀N₂O₆
Molecular Weight:420.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

α-Glucosidase-IN-11 Chemical Structure

CAS No.: 2411744-76-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

α-Glucosidase-IN-11 (compound 3k) inhibits α-glucosidase, α-fucosidase and α-mannosidase with the IC₅₀ value of 0.56 μM, 30.4 μM and 41.2 μM, respectively^[1].
α-Glucosidase-IN-11 (compound 3k) ( 0.1-100 μM, 24 hours) can induce β-cell proliferation at lower concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

BRIN-BD11 cells (rat beta cell line)
Concentration:

0.1-100 μM
Incubation Time:

24 hours
Result:

Showed cell proliferation at low concentration of 1 μM and minor cytotoxic effect at higher concentration greater than 10 μM.

In Vivo

α-Glucosidase-IN-11 (compound 3k) (gastric gavage, 60 mg/kg, everyday, 4 weeks) can improve blood glucose levels during fasting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague Dawley rats (250e320g)^[1]
Dosage:

60 mg/kg
Administration:

Gastric gavage; everyday; 4 weeks
Result:

Caused a significant drop in fasting blood glucose during the first and second weeks but did not cause a decrease in non-fasting blood glucose for up to four weeks.

Chemical Information

CAS No. 2411744-76-6
Molecular Weight 420.41
Formula C₂₃H₂₀N₂O₆
SMILES

O=C(OCC)C1=CC=C(N2C(CO)=CC=C2/C=C3OC(C4=C\3C=C(C)NC4=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tania Luthra, et al. Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes. Eur J Med Chem. 2020 Feb 15;188:112034. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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α-Glucosidase-IN-11

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

α-Glucosidase-IN-11 Related Classifications

HY-150560 Related Classifications