α-Glucosidase-IN-43
α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC50: 4.32 μM) with acute hypoglycemic activity. α-Glucosidase-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin (HY-13753)-induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients.
For research use only. We do not sell to patients.
- CAS No.: 3018963-27-1
- Formula: C27H31N3O4
- Molecular Weight:461.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 4.32 μM (α-Glucosidase)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| L929 | IC50 |
>100 μM
Compound: AS14
|
Cytotoxicity against mouse L929 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 37984299] |
Chemical Information
-
CAS No. 3018963-27-1
-
Molecular Weight 461.55
-
Formula C27H31N3O4
-
SMILES
O=C1C=C(OCCCCCN2N=NC(COC3=CC(C(C)C)=CC=C3C)=C2)C4=C(O1)C=CC=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)