β-Amyrone  (Synonyms: β-Amyron)

β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity^[1][2][3][4].

β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO^∙ production in LPS-stimulated J774 cells, with an IC₅₀ value of 4.61 μg/mL, and has no obvious effect on cell viability^[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells^[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC₅₀ value of 86 uM^[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC₅₀ values of 25 μM, 23 μM and 8 μg/mL, respectively^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

424.70

C₃₀H₄₈O

638-97-1

Solid

White to off-white

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CCC(C)(C4)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC2)C)C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Patrícia D O de Almeida, et al. Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins. Evid Based Complement Alternat Med. 2015;2015:293768.  [Content Brief]

  [2]. Mélanie Bourjot, et al. Chemical constituents of Anacolosa pervilleana and their antiviral activities. Fitoterapia. 2012 Sep;83(6):1076-80.  [Content Brief]

  [3]. Ki-Kwang Oh, et al. Elucidating Drug-Like Compounds and Potential Mechanisms of Corn Silk ( Stigma Maydis) against Obesity: A Network Pharmacology Study. Curr Issues Mol Biol. 2021 Nov 6;43(3):1906-1936.  [Content Brief]

  [4]. Ata A, et al. Chemical constituents of Drypetes gossweileri and their enzyme inhibitory and anti-fungal activities. Phytochemistry Letters, 2011, 4(1): 34-37.