2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. α-Glucosidase-IN-15

α-Glucosidase-IN-15 (Compound 14B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.34 μM. α-Glucosidase-IN-15 shows antidiabetic activity.

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α-Glucosidase-IN-15

α-Glucosidase-IN-15 Chemische Struktur

CAS. Nr. : 2820424-85-7

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α-Glucosidase-IN-15 Related Antibodies

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Beschreibung

α-Glucosidase-IN-15 (Compound 14B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.34 μM. α-Glucosidase-IN-15 shows antidiabetic activity[1].

IC50 & Target

IC50: 3.34 μM (α-glucosidase)[1]
In Vivo

α-Glucosidase-IN-15 (Compound 14B) (10 and 20 mg/kg; p.o.; b.w. for 4 weeks) shows antidiabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].
α-Glucosidase-IN-15 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].
α-Glucosidase-IN-15 (2000mg/kg; p.o.; b.w. for 2 weeks) demonstrates no mortality in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats (170–200 g), Streptozotocin-induced diabetes model[1]
Dosage: 10 and 20 mg/kg
Administration: Oral administration, b.w. for 4 weeks
Result: Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.
Molekulargewicht

372.53

Formel

C24H24N2S
CAS. Nr.
SMILES

CC1=CC=C(C2=NC3=C(C=CC=C3)SC(C4=CC=C(N(C)C)C=C4)C2)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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α-Glucosidase-IN-15 Related Classifications

  • Molaritätsrechner

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-152820424-85-7Glycosidasediabetesorally activeanti-hyperglycemicInhibitorinhibitorinhibit

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