2-Boc-2,6-Diazaspiro[3.3]heptane
Based on 1 Customer Validation
2-Boc-2,6-Diazaspiro[3.3]heptane is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 98.69%
- CAS No.: 1041026-70-3
- Formula: C10H18N2O2
- Molecular Weight:198.27
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
![2-Boc-2,6-Diazaspiro[3.3]heptane Chemical Structure](https://file.medchemexpress.com/product_pic/hy-30843.gif "Click to View 2-Boc-2,6-Diazaspiro[3.3]heptane Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E234 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1041026-70-3
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Appearance Solid
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Molecular Weight 198.27
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Formula C10H18N2O2
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Color White to off-white
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SMILES
O=C(OC(C)(C)C)N1CC2(CNC2)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (126.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (243 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.0436 mL | 25.2181 mL | 50.4363 mL | 126.0907 mL |
| 5 mM | 1.0087 mL | 5.0436 mL | 10.0873 mL | 25.2181 mL | |
| 10 mM | 0.5044 mL | 2.5218 mL | 5.0436 mL | 12.6091 mL | |
| 15 mM | 0.3362 mL | 1.6812 mL | 3.3624 mL | 8.4060 mL | |
| 20 mM | 0.2522 mL | 1.2609 mL | 2.5218 mL | 6.3045 mL | |
| 25 mM | 0.2017 mL | 1.0087 mL | 2.0175 mL | 5.0436 mL | |
| 30 mM | 0.1681 mL | 0.8406 mL | 1.6812 mL | 4.2030 mL | |
| 40 mM | 0.1261 mL | 0.6305 mL | 1.2609 mL | 3.1523 mL | |
| 50 mM | 0.1009 mL | 0.5044 mL | 1.0087 mL | 2.5218 mL | |
| 60 mM | 0.0841 mL | 0.4203 mL | 0.8406 mL | 2.1015 mL | |
| 80 mM | 0.0630 mL | 0.3152 mL | 0.6305 mL | 1.5761 mL | |
| 100 mM | 0.0504 mL | 0.2522 mL | 0.5044 mL | 1.2609 mL |
2-Boc-2,6-Diazaspiro[3.3]heptane Related Classifications
HY-30843 Related Classifications
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