3-(3-Phenoxybenzyl)amino-β-carboline
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 1327080-54-5
- Formula: C24H19N3O
- Molecular Weight:365.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780S | IC50 |
45 nM
Compound: 2
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Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 35084853] |
| HeLa | IC50 |
51 nM
Compound: 2
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 35084853] |
| HeLa S3 | IC50 |
0.074 μM
Compound: 10e
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Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
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[PMID: 22520257] |
| HeLa S3 | IC50 |
0.074 μM
Compound: 2h
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Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
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[PMID: 21752645] |
| MCF7 | IC50 |
49 nM
Compound: 2
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 35084853] |
| NCI-H460 | IC50 |
62 nM
Compound: 2
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Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 35084853] |
| Raji | IC50 |
31 nM
Compound: 2
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Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 35084853] |
| Sarcoma-180 | IC50 |
0.03 μM
Compound: 10e
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Cytotoxicity against mouse Sarcoma 180 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against mouse Sarcoma 180 cells after 24 to 72 hrs by MTT assay
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[PMID: 22520257] |
In Vitro
3-(3-Phenoxybenzyl)amino-β-carboline specifically denatures tubulin, making it prone to aggregation that predisposes it to ubiquitinylation and then degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1327080-54-5
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Molecular Weight 365.43
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Formula C24H19N3O
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SMILES
C(N1)(C=NC(NCC2=CC=CC(OC3=CC=CC=C3)=C2)=C4)=C4C5=C1C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-(3-Phenoxybenzyl)amino-β-carboline Related Classifications
HY-150511 Related Classifications
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