3'-Azido-3'-deoxyadenosine
Based on 1 Customer Validation
3'-Azido-3'-deoxyadenosine is a purine nucleoside analog. 3'-Azido-3'-deoxyadenosine acts as a click chemistry reagent bearing an Azide group, which undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group. 3'-Azido-3'-deoxyadenosine also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 98.44%
- CAS No.: 58699-62-0
- Formula: C10H12N8O3
- Molecular Weight:292.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
3'-Azido-3'-deoxyadenosine can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 58699-62-0
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Appearance Solid
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Molecular Weight 292.25
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Formula C10H12N8O3
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Color White to off-white
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SMILES
OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1N=[N+]=[N-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (427.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Robak T, et al. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-3388. [Content Brief]
[2]. Steger J, et al. Efficient access to nonhydrolyzable initiator tRNA based on the synthesis of 3'-azido-3'-deoxyadenosine RNA. Angew Chem Int Ed Engl. 2010 Oct 4;49(41):7470-2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4217 mL | 17.1086 mL | 34.2173 mL | 85.5432 mL |
| 5 mM | 0.6843 mL | 3.4217 mL | 6.8435 mL | 17.1086 mL | |
| 10 mM | 0.3422 mL | 1.7109 mL | 3.4217 mL | 8.5543 mL | |
| 15 mM | 0.2281 mL | 1.1406 mL | 2.2812 mL | 5.7029 mL | |
| 20 mM | 0.1711 mL | 0.8554 mL | 1.7109 mL | 4.2772 mL | |
| 25 mM | 0.1369 mL | 0.6843 mL | 1.3687 mL | 3.4217 mL | |
| 30 mM | 0.1141 mL | 0.5703 mL | 1.1406 mL | 2.8514 mL | |
| 40 mM | 0.0855 mL | 0.4277 mL | 0.8554 mL | 2.1386 mL | |
| 50 mM | 0.0684 mL | 0.3422 mL | 0.6843 mL | 1.7109 mL | |
| 60 mM | 0.0570 mL | 0.2851 mL | 0.5703 mL | 1.4257 mL | |
| 80 mM | 0.0428 mL | 0.2139 mL | 0.4277 mL | 1.0693 mL | |
| 100 mM | 0.0342 mL | 0.1711 mL | 0.3422 mL | 0.8554 mL |
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