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Cat. No.: HY-N13079

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3-Epicinobufagin

3-Epicinobufagin (compound IX) can be used as an internal standard for the metabolism of Bufalin (HY-N0877), by detecting its content in serum and urine to provide feedback on the corresponding metabolic status.

For research use only. We do not sell to patients.

CAS No.: 36121-84-3
Formula: C₂₆H₃₄O₆
Molecular Weight:442.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

3-Epicinobufagin Chemical Structure

CAS No.: 36121-84-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.3 μM Compound: 12b	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32526552]
A549	IC₅₀	6.5 μM Compound: 8	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 24050254]
BEAS-2B	IC₅₀	22.3 μM Compound: 12b	Cytotoxicity against human BEAS-2B assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human BEAS-2B assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32526552]
Bel-7402	IC₅₀	0.1 μM Compound: 1	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 18558746]
Bel-7402	IC₅₀	4.9 x 10^-2μM Compound: CB	Cytotoxicity against human Bel7402 cells assessed as againsthibition of cell growth after 72 hrs Cytotoxicity against human Bel7402 cells assessed as againsthibition of cell growth after 72 hrs	[PMID: 21205911]
Calu-3	IC₅₀	2.3 μM Compound: 12b	Antiproliferative activity against human Calu-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human Calu-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32526552]
CCRF S-180	IC₅₀	>50 μM Compound: 2	Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23799775]
CNE	IC₅₀	0.31 μM Compound: 2	Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23799775]
CNE2Z	IC₅₀	0.39 μM Compound: 2	Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23799775]
H22	IC₅₀	>50 μM Compound: 2	Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23799775]
HepG2	IC₅₀	1.706 μM Compound: 2	Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23799775]
HepG2	IC₅₀	2.355 μM Compound: 2	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23799775]
HepG2	IC₅₀	5.5 μM Compound: 8	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 24050254]
HL-60	IC₅₀	<0.01 μg/mL Compound: 12	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 11575946]
KB	IC₅₀	0.21 μg/mL Compound: 12	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 11575946]
MH60	IC₅₀	>25 μg/mL Compound: 12	Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay	[PMID: 11575946]
MH60	IC₅₀	>56.3 μM Compound: 9	Growth inhibition of IL6-dependent mouse MH60 cells after 72 hrs by MTT assay in presence of human recombinant IL6 Growth inhibition of IL6-dependent mouse MH60 cells after 72 hrs by MTT assay in presence of human recombinant IL6	[PMID: 15620253]
MH60	IC₅₀	>56.3 μM Compound: 9	Growth inhibition of IL-6-independent mouse MH60 cells after 72 hrs by MTT assay Growth inhibition of IL-6-independent mouse MH60 cells after 72 hrs by MTT assay	[PMID: 15620253]
NCI-H1299	IC₅₀	2.3 μM Compound: 12b	Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32526552]
NCI-H460	IC₅₀	2.3 μM Compound: 12b	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32526552]
SK-MES-1	IC₅₀	2.3 μM Compound: 12b	Antiproliferative activity against human SK-MES-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-MES-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 32526552]

Chemical Information

CAS No. 36121-84-3
Molecular Weight 442.54
Formula C₂₆H₃₄O₆
SMILES

C[C@]12[C@@]3([C@@]4([H])[C@]([C@@]5([C@](C[C@@H](CC5)O)([H])CC4)C)([H])CC2)[C@]([C@@H]([C@@H]1C(C=C6)=COC6=O)OC(C)=O)([H])O3
Structure Classification
- Steroids
Initial Source
- Animals
Chinese toad venom preparation Ch'an Su were
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang L, et al. Simultaneous determinations of cinobufagin and its metabolites by reverse-phase high performance liquid chromatography in rat serum and urine[J]. Journal of liquid chromatography, 1990, 13(17): 3515-3530.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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