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Cat. No.: HY-137983

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3-O-Acetylbetulin

(Synonyms: 3-Acetylbetulin)

3-O-Acetylbetulin is a derivative of Betulin (HY-N0083), a sterol regulatory element-binding protein (SREBP) inhibitor. 3-O-Acetylbetulin can be utilized in synthesis of other betulin derivatives.

For research use only. We do not sell to patients.

CAS No.: 27570-20-3
Formula: C₃₂H₅₂O₃
Molecular Weight:484.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

3-O-Acetylbetulin Chemical Structure

CAS No.: 27570-20-3

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	EC₅₀	>30 μM Compound: 2	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 27142753]
518A2	EC₅₀	15.2 μM Compound: 30	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 26547057]
A2780	EC₅₀	11 μM Compound: 30	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 26547057]
A2780	EC₅₀	28.5 μM Compound: 2	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 27142753]
A2780	EC₅₀	28.5 μM Compound: 28	Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay	[PMID: 31718946]
A-375	EC₅₀	>30 μM Compound: 28	Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay	[PMID: 31718946]
A549	EC₅₀	>30 μM Compound: 2	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 27142753]
A549	EC₅₀	14 μM Compound: 30	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 26547057]
FaDu	EC₅₀	>30 μM Compound: 28	Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay	[PMID: 31718946]
HeLa	EC₅₀	>30 μM Compound: 2	Cytotoxicity against human HeLa cells after 96 hrs by SRB assay Cytotoxicity against human HeLa cells after 96 hrs by SRB assay	[PMID: 27142753]
HT-29	EC₅₀	>30 μM Compound: 2	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 27142753]
HT-29	EC₅₀	>30 μM Compound: 28	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay	[PMID: 31718946]
MCF7	EC₅₀	11.2 μM Compound: 30	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 26547057]
MCF7	EC₅₀	20.2 μM Compound: 2	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 27142753]
MCF7	EC₅₀	20.2 μM Compound: 28	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay	[PMID: 31718946]
NIH3T3	EC₅₀	>30 μM Compound: 28	Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay	[PMID: 31718946]
NIH3T3	EC₅₀	>30 μM Compound: 30	Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay	[PMID: 26547057]

Chemical Information

CAS No. 27570-20-3
Molecular Weight 484.75
Formula C₃₂H₅₂O₃
SMILES

CC1(C)[C@@H](OC(C)=O)CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](CO)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Synonyms

3-Acetylbetulin
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Flekhter, O.B., et al. The synthesis and hepatoprotective activity of esters of the lupane group triterpenoids. Russ J Bioorg Chem 26, 192–200 (2000).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Purity & Documentation
References

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3-O-Acetylbetulin

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Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

3-O-Acetylbetulin Related Classifications

HY-137983 Related Classifications