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Cat. No.: HY-123489S

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3α,21-Dihydroxy-5α-pregnan-20-one-d₃

Name: 3α,21-Dihydroxy-5α-pregnan-20-one-d3
Brand: MedChemExpress
SKU: HY-123489S
Availability: PreOrder

(Synonyms: THDOC-d₃)

3α,21-Dihydroxy-5α-pregnan-20-one-d₃ is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

For research use only. We do not sell to patients.

CAS No.: 203805-98-5
Formula: C₂₁H₃₁D₃O₃
Molecular Weight:337.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

3α,21-Dihydroxy-5α-pregnan-20-one-d₃ Chemical Structure

CAS No.: 203805-98-5

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Biological Activity
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Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 203805-98-5
Unlabeled CAS 567-02-2
Molecular Weight 337.51
Formula C₂₁H₃₁D₃O₃
SMILES

C[C@@]12[C@](CC[C@]2([2H])C(C([2H])([2H])O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@@](C[C@@H](CC4)O)([H])CC3)C
Synonyms

THDOC-d₃
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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3α,21-Dihydroxy-5α-pregnan-20-one-d₃

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3α,21-Dihydroxy-5α-pregnan-20-one-d3

Biological Activity

Description

In Vitro

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

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HY-123489S Related Classifications

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