3α,21-Dihydroxy-5α-pregnan-20-one
Based on 1 Customer Validation
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 567-02-2
- Formula: C21H34O3
- Molecular Weight:334.49
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 567-02-2
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Appearance Solid
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Molecular Weight 334.49
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Formula C21H34O3
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Color White to off-white
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SMILES
C[C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(C[C@@H](CC[C@@]4([C@]3(CC2)[H])C)O)[H])[H])[H])C(CO)=O
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Synonyms
THDOC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (298.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (245 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9896 mL | 14.9481 mL | 29.8963 mL | 74.7407 mL |
| 5 mM | 0.5979 mL | 2.9896 mL | 5.9793 mL | 14.9481 mL | |
| 10 mM | 0.2990 mL | 1.4948 mL | 2.9896 mL | 7.4741 mL | |
| 15 mM | 0.1993 mL | 0.9965 mL | 1.9931 mL | 4.9827 mL | |
| 20 mM | 0.1495 mL | 0.7474 mL | 1.4948 mL | 3.7370 mL | |
| 25 mM | 0.1196 mL | 0.5979 mL | 1.1959 mL | 2.9896 mL | |
| 30 mM | 0.0997 mL | 0.4983 mL | 0.9965 mL | 2.4914 mL | |
| 40 mM | 0.0747 mL | 0.3737 mL | 0.7474 mL | 1.8685 mL | |
| 50 mM | 0.0598 mL | 0.2990 mL | 0.5979 mL | 1.4948 mL | |
| 60 mM | 0.0498 mL | 0.2491 mL | 0.4983 mL | 1.2457 mL | |
| 80 mM | 0.0374 mL | 0.1869 mL | 0.3737 mL | 0.9343 mL | |
| 100 mM | 0.0299 mL | 0.1495 mL | 0.2990 mL | 0.7474 mL |
3α,21-Dihydroxy-5α-pregnan-20-one Related Classifications
HY-123489 Related Classifications
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