4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl
4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl is a bibenzyl compound found in Dendrobium secundum. 4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl exhibits cytotoxicity against KB human oral epidermoid carcinoma cells, NCI‑H187 human non-small cell lung cancer cells, and MCF‑7 human breast cancer cells. 4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1362114-29-1
- Formula: C16H18O5
- Molecular Weight:290.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
48.3 μM
|
Cytotoxic activity against human KB oral epidermoid carcinoma cells measured by in vitro cytotoxicity assay.
Cytotoxic activity against human KB oral epidermoid carcinoma cells measured by in vitro cytotoxicity assay.
|
10286020.2012.689979 |
| NCI-H187 | IC50 |
63.8 μM
|
Cytotoxic activity against human NCI-H187 small cell lung cancer cells measured by in vitro cytotoxicity assay.
Cytotoxic activity against human NCI-H187 small cell lung cancer cells measured by in vitro cytotoxicity assay.
|
10286020.2012.689979 |
| MCF7 | IC50 |
62.6 μM
|
Cytotoxic activity against human MCF-7 breast cancer cells measured by in vitro cytotoxicity assay.
Cytotoxic activity against human MCF-7 breast cancer cells measured by in vitro cytotoxicity assay.
|
10286020.2012.689979 |
In Vitro
4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl (compound 11) exerts cytotoxic effects on the KB, NCI-H187, and MCF-7 human cancer cell lines, with IC50 values of 48.3 μM, 63.8 μM, and 62.6 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1362114-29-1
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Molecular Weight 290.32
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Formula C16H18O5
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SMILES
OC1=CC=C(C=C1OC)CCC2=CC(O)=C(O)C(OC)=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)