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8-Bromo-ATP

(Synonyms: 8-Bromoadenosine 5'-triphosphate; 8-Br-ATP)

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC₅₀ of 23.1 μM.

For research use only. We do not sell to patients.

CAS No.: 23567-97-7
Formula: C₁₀H₁₅BrN₅O₁₃P₃
Molecular Weight:586.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

8-Bromo-ATP Chemical Structure

CAS No.: 23567-97-7

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC₅₀ of 23.1 μM^[1]^[2]^[3].

All P2X Receptor Isoforms :

In Vitro

8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma^[3].
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

MM 1.s cells
Concentration:

10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time:

5 days
Result:

Showed cytotoxic to multiple myeloma.

Chemical Information

CAS No. 23567-97-7
Molecular Weight 586.08
Formula C₁₀H₁₅BrN₅O₁₃P₃
SMILES

O=P(O)(O)OP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(Br)=NC3=C(N)N=CN=C23)O1)(O)=O)(O)=O
Synonyms

8-Bromoadenosine 5'-triphosphate; 8-Br-ATP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder). Eur. J. Med. Chem. 23(5), 433-439 (1988).

[2]. P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263(25):12288-94. [Content Brief]

[3]. Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21(4):306-14. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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