Enterodiol

Cat. No.: HY-108695: FAQs
Data Sheet Handling Instructions

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Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities.

For research use only. We do not sell to patients.

Enterodiol Chemical Structure

CAS No. : 80226-00-2

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Other Forms of Enterodiol:

(±)-Enterodiol Get quote

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Biological Activity
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References
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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Enterodiol (0-100 μM; 24-72 hours) results in an apoptosis rate of up to 40% in CT26 cells. Enterodiol shows no cytotoxicity toward RAW264.7 macrophages^[1].
Enterodiol (0-100 μM; 24-48 hours) also suppresses the migration of CRC cells in a concentration-dependent manner. The phosphorylation of ERK, JNK, and p38 is down-regulated with Enterodiol treatment. Enterodiol (0-100 μM; 48 hours) decreases the expression levels of anti-apoptotic proteins in CRC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enterodiol (1 mg/kg; intra-tumor injection method; once every other day until day 32) suppresses tumor markedly^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	4-8 weeks old female BALB/c nude mice^[2]
Dosage:	1 mg/kg
Administration:	Intra-tumor injection method; once every other day until day 32
Result:	A significant reduction in the tumor volume in the experimental groups compared to the PBS group.

Molecular Weight

302.36

Formula

C₁₈H₂₂O₄

CAS No.

80226-00-2

SMILES

OC[C@H](CC1=CC=CC(O)=C1)[C@@H](CC2=CC=CC(O)=C2)CO

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shin MK, et al. Apoptotic effect of enterodiol, the final metabolite of edible lignans, in colorectal cancer cells. J Sci Food Agric. 2019;99(5):2411-2419. [Content Brief]

[2]. Liu H, et al. Enterolactone has stronger effects than enterodiol on ovarian cancer. J Ovarian Res. 2017;10(1):49. Published 2017 Jul 24. [Content Brief]

Enterodiol Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enterodiol80226-00-2ApoptosisEndogenous MetabolitelignanscolorectalcancerCRCphosphorylationcytotoxicitymacrophagesInhibitorinhibitorinhibit

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