1. Apoptosis
    Metabolic Enzyme/Protease
  2. Apoptosis
    Endogenous Metabolite
  3. Enterodiol

Enterodiol 

Cat. No.: HY-108695
Handling Instructions

Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities.

For research use only. We do not sell to patients.

Enterodiol Chemical Structure

Enterodiol Chemical Structure

CAS No. : 80226-00-2

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Description

Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Enterodiol (0-100 μM; 24-72 hours) results in an apoptosis rate of up to 40% in CT26 cells. Enterodiol shows no cytotoxicity toward RAW264.7 macrophages[1].
Enterodiol (0-100 μM; 24-48 hours) also suppresses the migration of CRC cells in a concentration-dependent manner. The phosphorylation of ERK, JNK, and p38 is down-regulated with Enterodiol treatment. Enterodiol (0-100 μM; 48 hours) decreases the expression levels of anti-apoptotic proteins in CRC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enterodiol (1 mg/kg; intra-tumor injection method; once every other day until day 32) suppresses tumor markedly[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-8 weeks old female BALB/c nude mice[2]
Dosage: 1 mg/kg
Administration: Intra-tumor injection method; once every other day until day 32
Result: A significant reduction in the tumor volume in the experimental groups compared to the PBS group.
Molecular Weight

302.36

Formula

C₁₈H₂₂O₄

CAS No.
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Enterodiol
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