1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. JNJ-17203212

JNJ-17203212 

Cat. No.: HY-100129 Purity: 99.94%
Handling Instructions

JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine.

For research use only. We do not sell to patients.

JNJ-17203212 Chemical Structure

JNJ-17203212 Chemical Structure

CAS No. : 821768-06-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 89 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 624 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1104 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine[1][2].

IC50 & Target[1]

TRPV1

 

In Vitro

JNJ-17203212 (0.5 μM) potently inhibits imperatorin-induced TRPV1 activation (Ca2+ increases) in TRPV1-expressing HEK cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JNJ-17203212 (0.3 mg/kg ; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression[2].
JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (260-300 g)[2]
Dosage: 0.3 mg/kg
Administration: Intravenous injection
Result: Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS.
Molecular Weight

419.32

Formula

C₁₇H₁₅F₆N₅O

CAS No.

821768-06-3

SMILES

O=C(N1CCN(C2=NC=CC=C2C(F)(F)F)CC1)NC3=NC=C(C(F)(F)F)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (238.48 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3848 mL 11.9241 mL 23.8481 mL
5 mM 0.4770 mL 2.3848 mL 4.7696 mL
10 mM 0.2385 mL 1.1924 mL 2.3848 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (6.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (6.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.94%

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Keywords:

JNJ-17203212JNJ17203212JNJ 17203212TRP ChannelTransient receptor potential channelsmigrainempainmanagementInhibitorinhibitorinhibit

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Product Name:
JNJ-17203212
Cat. No.:
HY-100129
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