Lucanthone

Name: Lucanthone
Brand: MedChemExpress
SKU: HY-B2098
Rating: 4.5 (0 reviews)

Cat. No.: HY-B2098 Purity: 99.63%: Data Sheet
COA

SDS
Handling Instructions
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Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Lucanthone 화학구조

CAS No. : 479-50-5

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Lucanthone:

Lucanthone hydrochloride 견적 받기
Lucanthone (Standard) 견적 받기

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Biological Activity
Protocol
순도&문서
References
고객리뷰

제품 설명

Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

IC₅₀ & Target

APE-1^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BT-20	IC₅₀	5.7 μM Compound: Lucanthone	Cytotoxicity against human BT20 cells after 72 hrs by MTT assay Cytotoxicity against human BT20 cells after 72 hrs by MTT assay	[PMID: 25699157]
BT-474	IC₅₀	5.7 μM Compound: Lucanthone	Cytotoxicity against human BT474 cells after 72 hrs by MTT assay Cytotoxicity against human BT474 cells after 72 hrs by MTT assay	[PMID: 25699157]
HCC1937	IC₅₀	5.7 μM Compound: Lucanthone	Cytotoxicity against human HCC1937 cells after 72 hrs by MTT assay Cytotoxicity against human HCC1937 cells after 72 hrs by MTT assay	[PMID: 25699157]
HCC1954	IC₅₀	5.7 μM Compound: Lucanthone	Cytotoxicity against human HCC1954 cells after 72 hrs by MTT assay Cytotoxicity against human HCC1954 cells after 72 hrs by MTT assay	[PMID: 25699157]
MDA-MB-231	IC₅₀	5.7 μM Compound: Lucanthone	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 25699157]
MDA-MB-435	IC₅₀	5.7 μM Compound: Lucanthone	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 25699157]
SK-BR-3	IC₅₀	5.7 μM Compound: Lucanthone	Cytotoxicity against human SKBR3 cells after 72 hrs by MTT assay Cytotoxicity against human SKBR3 cells after 72 hrs by MTT assay	[PMID: 25699157]
Vero 76	IC₅₀	12.4 μM Compound: 19	Cytotoxicity against green monkey Vero 76 cells incubated for 48 to 96 hrs by crystal violet staining assay Cytotoxicity against green monkey Vero 76 cells incubated for 48 to 96 hrs by crystal violet staining assay	[PMID: 36753881]

In Vitro

Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC₅₀ of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

분자량

340.48

화학식

C₂₀H₂₄N₂OS

CAS No.

479-50-5

Appearance

Solid

Color

Off-white to orange

SMILES

O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CC)CC

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 25 mg/mL (73.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9370 mL	14.6852 mL	29.3703 mL
5 mM	0.5874 mL	2.9370 mL	5.8741 mL
10 mM	0.2937 mL	1.4685 mL	2.9370 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.63%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (250 KB) HNMR (192 KB) LCMS (170 KB)

Handling Instructions (2659 KB)

References

[1]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18. [Content Brief]

[2]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13. [Content Brief]

Cell Assay
^[2]

Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G₀/G₁ DNA content^[2].

MCE 는 독립적으로 이러한 방법들의 정확성을 확인하지 않았습니다. 참고용으로만 봐주십시오.

References

[1]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18. [Content Brief]

[2]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9370 mL	14.6851 mL	29.3703 mL	73.4257 mL
	5 mM	0.5874 mL	2.9370 mL	5.8741 mL	14.6851 mL
	10 mM	0.2937 mL	1.4685 mL	2.9370 mL	7.3426 mL
	15 mM	0.1958 mL	0.9790 mL	1.9580 mL	4.8950 mL
	20 mM	0.1469 mL	0.7343 mL	1.4685 mL	3.6713 mL
	25 mM	0.1175 mL	0.5874 mL	1.1748 mL	2.9370 mL
	30 mM	0.0979 mL	0.4895 mL	0.9790 mL	2.4475 mL
	40 mM	0.0734 mL	0.3671 mL	0.7343 mL	1.8356 mL
	50 mM	0.0587 mL	0.2937 mL	0.5874 mL	1.4685 mL
	60 mM	0.0490 mL	0.2448 mL	0.4895 mL	1.2238 mL

Lucanthone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lucanthone479-50-5AutophagyParasiteInhibitorinhibitorinhibit

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Lucanthone

고객리뷰

Other Forms of Lucanthone:

Lucanthone Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

Biological Activity

Protocol

순도&문서

References

고객리뷰

Lucanthone Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Lucanthone Related Classifications

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SAFETY DATA SHEET (SDS)

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