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Methylene Blue

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

14

Fluorescent Dye

4

Biochemical Assay Reagents

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14536
    Methylene Blue
    Maximum Cited Publications
    28 Publications Verification

    Basic Blue 9; CI-52015; Methylthioninium chloride

    		 Environmental Pollutants Monoamine Oxidase Guanylate Cyclase Microtubule/Tubulin NO Synthase Infection Neurological Disease Cancer
    Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene Blue is a photosensitizer and redox agent. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
    Methylene Blue
  • HY-W751238
    Dimethyl methylene blue zinc chloride double salt

    DMMB

    		 Fluorescent Dye Others
    Dimethyl methylene blue zinc chloride double salt (DMMB) is a cationic dye. Dimethyl methylene blue zinc chloride double salt competitively binds to the active site of the PANI-Benz-Ag nanocomposite with endotoxin, releasing DMMB and increasing the fluorescence intensity. Dimethyl methylene blue zinc chloride double salt can be used as a fluorescent probe for the detection of bacteria (such as E. Coli) endotoxin . Dimethyl methylene blue zinc chloride double salt can be used for the quantification of sulfated glycosaminoglycans .
    Dimethyl methylene blue zinc chloride double salt
  • HY-136278
    DETA NONOate
    5+ Cited Publications

    Diethylamine NONOate; NOC-18

    		 NO Synthase Cardiovascular Disease
    DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting .
    DETA NONOate
  • HY-B1359
    Methylene blue trihydrate
    Maximum Cited Publications
    28 Publications Verification

    C.I. Basic Blue 9 trihydrate

    		 Guanylate Cyclase Monoamine Oxidase NO Synthase Parasite Infection Neurological Disease Cancer
    Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment .
    Methylene blue trihydrate
  • HY-118462
    Coelenteramine 400a

    Coelenterazine 400a; Bisdeoxycoelenterazine

    		 Fluorescent Dye Others
    Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .
    Coelenteramine 400a
  • HY-B1359A
    Methylene blue indicator
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Methylene blue indicator is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Methylene blue indicator
  • HY-19948
    Leucomethylene blue mesylate
    5+ Cited Publications

    TRx0237 mesylate; Methylene Blue leuco base mesylate

    		 Tau Protein Neurological Disease
    Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes .
    Leucomethylene blue mesylate
  • HY-D0944
    Giemsa stain
    2 Publications Verification

    		 Fluorescent Dye Others
    Giemsa stain is a composite dye composed of methylene azure, methylene blue, eosin and other components. Giemsa stain stains chromatin, nuclear membranes, specific cytoplasmic components and microorganisms. Giemsa stain is used in research on cytological and parasitological staining .
    Giemsa stain
  • HY-D0004
    Azure B

    Azure B chloride

    		 Monoamine Oxidase Neurological Disease
    Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .
    Azure B
  • HY-D0958
    Methylene blue hydrate
    20+ Cited Publications

    Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate

    		 Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin Infection Inflammation/Immunology Cancer
    Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
    Methylene blue hydrate
  • HY-14536A
    Methylene blue (purity≥70%)

    Basic Blue 9 (purity≥70%); CI-52015 (purity≥70%); Methylthioninium chloride (purity≥70%)

    		 Environmental Pollutants Monoamine Oxidase Guanylate Cyclase Microtubule/Tubulin NO Synthase Infection Neurological Disease Cancer
    Methylene blue (purity≥70%) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue (purity≥70%) is a vasopressor and is often used as a dye in several medical procedures. Methylene blue (purity≥70%) through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue (purity≥70%) is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue (purity≥70%) is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
    Methylene blue (purity≥70%)
  • HY-169798
    1,9-Dimethylmethylene blue

    		Fluorescent Dye VSV Infection
    1,9-Dimethylmethylene blue is a photosensitizer, virus inactivator and hemoglobin oxidant derived from methylene blue. When activated, 1,9-Dimethylmethylene blue generates reactive oxygen species including singlet oxygen, and acts as a metachromatic dye. When activated in monomeric or dimeric form, 1,9-Dimethylmethylene blue induces photoinactivation of R17 phage and vesicular stomatitis virus and oxidizes hemoglobin via non-singlet oxygen reactive oxygen species or singlet oxygen-mediated pathways, respectively. The monomeric form, with higher nucleic acid affinity, achieves virus inactivation under specific conditions without forming methemoglobin. 1,9-Dimethylmethylene blue binds to substances such as glycosaminoglycans to produce color changes. Although it is susceptible to interference from non-glycosaminoglycan components in urine, it is still applicable to spectrophotometric analysis for glycosaminoglycan quantification. With these unique photochemical and binding properties, 1,9-Dimethylmethylene blue is widely used in studies of viral infections and related biochemical analyses .
    1,9-Dimethylmethylene blue
  • HY-W143216
    Azure C

    Monomethylthionine

    		 Amyloid-β Tau Protein Neurological Disease
    Azure C acts as a tau oligomer modulator and Aβ42 oligomerization inhibitor. It regulates hsp70 ATPase activity, thereby mediating the clearance of tau protein. Azure C reduces the levels of toxic tau oligomers by promoting the formation of non-toxic tau aggregates, rescues neuroblastoma cells from tau oligomer-induced toxicity, and binds to and inhibits Aβ42 oligomerization without suppressing its fibrillization. Azure C is generated via sequential oxidation of methylene blue or Azure B through a horseradish peroxidase-mediated reaction, and accumulates in HRP reaction media. Azure C can be used in studies related to tauopathies, including Alzheimer's disease .
    Azure C
  • HY-W345885
    Saccharic acid

    		β-glucuronidase Metabolic Disease
    Saccharic acid is a competitive and potent inhibitor of β-glucuronidase. Saccharic acid inhibits glucuronide synthesis. Saccharic acid as an efficient iron chelate to enhance photo-Fenton
    degradation of organic contaminants .
    Saccharic acid
  • HY-W088068
    Wright's stain

    		Fluorescent Dye Others
    Wright's stain is a composite cell stain that mainly binds to intracellular nucleic acids, proteins and other components through thiazine dyes (such as methylene blue) and eosin. Wright's stain is pH-dependent (optimal pH 6.4-6.7) and achieves cell morphology resolution by differentially staining the cytoplasm and nucleus. Under alkaline conditions, thiazine dyes bind to nucleic acids to form purple, and acidic eosin binds to cytoplasmic proteins to form red, which can form contrasting cell morphological features. Wright's stain can clearly display the fine structures of blood cells and bone marrow cells (such as nuclear chromatin and granules) and quickly evaluate cell morphological abnormalities .
    Wright's stain
  • HY-109116
    Hydromethylthionine

    LeukoMethylene Blue

    		 Biochemical Assay Reagents Others
    Hydromethylthionine (Leukomethylene blue) has a very active photochemically active reagent, especially in its interaction with dissolved oxygen. The photochemical activity of Hydromethylthionine is mainly regulated by the reaction of its triplet state with dissolved oxygen, which reacts with dissolved oxygen to form Methylene Blue (HY-14536) and hydronium ions under ultraviolet light. Hydromethylthionine can be used for the photodegradation of model pollutants in semiconductor photocatalysis and for the study of indicators in chemical analysis .
    Hydromethylthionine
  • HY-D0929
    Orange I

    α-Naphthol Orange

    		 Fluorescent Dye Others
    Orange I (α-Naphthol Orange) is an anionic azo dye that can form a complex with Methylene blue (HY-14536) and cause fluorescence quenching. The equilibrium constant of the complex of Orange I and Methylene blue is 79900 mol -1·dm 3. Orange I can change the absorption spectrum of itself and Methylene blue .
    Orange I
  • HY-14536R
    Methylene Blue (Standard)

    Basic Blue 9 (Standard); CI-52015 (Standard); Methylthioninium chloride (Standard)

    		 Reference Standards Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin Infection Neurological Disease Cancer
    Methylene Blue (Standard) is the analytical standard of Methylene Blue. This product is intended for research and analytical applications. Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
    Methylene Blue (Standard)
  • HY-D0958R
    Methylene blue hydrate (Standard)

    Basic Blue 9 hydrate (Standard); CI-52015 hydrate (Standard); Methylthioninium chloride hydrate (Standard)

    		 Reference Standards Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin Infection Inflammation/Immunology Cancer
    Methylene blue (hydrate) (Standard) is the analytical standard of Methylene blue (hydrate). This product is intended for research and analytical applications. Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
    Methylene blue hydrate (Standard)
  • HY-157352
    Eosin-Methylene Blue Agar

    EMB Agar

    		 Biochemical Assay Reagents Others
    Eosin-Methylene Blue Agar (EMB Agar) is a biochemical reagent that can be used for microbial culture .
    Eosin-Methylene Blue Agar
  • HY-118462A
    Coelenteramine 400a hydrochloride

    Coelenterazine 400a hydrochloride; Bisdeoxycoelenterazine hydrochloride

    		 Fluorescent Dye Others
    Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .
    Coelenteramine 400a hydrochloride
  • HY-178115
    MB-Buf

    		Glutathione Peroxidase Apoptosis Ferroptosis Reactive Oxygen Species (ROS) Cancer
    MB-Buf is a conjugation of methylene blue (HY-14536) and bufalin (HY-N0877) . MB-Buf can targeting degrade GPX4 upon light activation. MB-Buf can induce cell apoptosis, ferroptosis, and ROS production. MB-Buf can be used for the research of cancer, such as breast cancer .
    MB-Buf
  • HY-W751874
    Acetyl methylene blue

    		Mitochondrial Metabolism Neurological Disease
    Acetyl methylene blue can be used to synthesize mitochondrial development stimulators, which can be used for eye diseases related to insufficient mitochondrial function in nerve cells .
    Acetyl methylene blue
  • HY-W015627
    3,5-Dichloropyridine

    		Drug Intermediate Inflammation/Immunology Cancer
    3,5-dichloropyridine is a drug intermediate that can be used to synthesize metal-organic framework (MOF) materials and P2X7 receptor antagonists .
    3,5-Dichloropyridine
  • HY-157364
    Levine Eosin-Methylene Blue Agar Medium

    Levine EMB Agar

    		 Biochemical Assay Reagents Others
    Levine Eosin-Methylene Blue Agar Medium (Levine EMB Agar) is a weakly selective medium for the isolation of intestinal pathogens, especially E. coli. The composition of 1 liter of Levine Eosin-Methylene Blue Agar Medium: 10.0 g Peptone, 10.0 g lactose, 2.0 g dipotassium hydrogen phosphate, 15.0 g agar, 0.4 g eosin, 0.065 g methylene blue .
    Levine Eosin-Methylene Blue Agar Medium
  • HY-D0004R
    Azure B (Standard)

    Azure B chloride (Standard)

    		 Reference Standards Monoamine Oxidase Neurological Disease
    Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .
    Azure B (Standard)
  • HY-D3140
    MB-m-borate

    		Fluorescent Dye Tyrosinase Cancer
    MB-m-borate is a double-locked near-infrared fluorescence-activated probe (Ex/Em ≈ 647 nm/684 nm). MB-m-borate undergoes cascade activation by hydrogen peroxide and tyrosinase to release the fluorophore methylene blue, thereby generating a fluorescence activation response. MB-m-borate enables precise detection of melanoma in melanoma cells and mouse models. MB-m-borate can be used for melanoma research .
    MB-m-borate
  • HY-W075708
    Cu(II) MTCPP

    Cu(II) Meso-Tetra(4-carboxyphenyl)porphyrin

    		 MOFs Others
    Cu (II) MTCPP (Cu (II) Meso-Tetra (4-carboxyphenyl) porphyrin) is a copper coordination complex. Cu (II) MTCPP-sensitized TiO2 nanotubes are a type of visible-light photocatalyst. Cu (II) MTCPP-sensitized TiO2 nanotubes can expand the wavelength response range, transfer excited electrons more efficiently, and separate photogenerated electron-hole pairs .
    Cu(II) MTCPP
  • HY-D3235
    FDOCl-22

    		Fluorescent Dye Endocrinology
    FDOCl-22 is a HOCl-responsive probe. FDOCl-22 reacts with hypochlorous acid to significantly enhance near-infrared emission and absorption signals, enabling the detection of HOCl levels associated with reagent-induced acute kidney injury. FDOCl-22 can be used in studies related to reagent-induced acute kidney injury .
    FDOCl-22

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