531-57-7
Chemical Structure
Azure C
Synonym(s): Monomethylthionine
- CAS No.: 531-57-7
- Formula:C13H12ClN3S
- Molecular Weight:277.78
IUPAC Name: 3-amino-7-(methylamino)phenothiazin-5-ium chloride
InChIKey: OBKVLZKRUVYQNQ-UHFFFAOYSA-M
SMILES: [Cl-].N=1C2=CC=C(N)C=C2[S+]=C3C=C(C=CC13)NC
Biological Activity: Azure C (Monomethylthionine) acts as a tau oligomer inhibitor and Aβ42 oligomerization inhibitor. Azure C regulates hsp70 ATPase activity, thereby mediating the clearance of tau protein. Azure C reduces the levels of toxic tau oligomers by promoting the formation of non-toxic tau aggregates, rescues neuroblastoma cells from tau oligomer-induced toxicity, and binds to and inhibits Aβ42 oligomerization. Azure C is generated via continuous oxidation of methylene blue or azure B through a horseradish peroxidase-mediated reaction. Azure C can be used in research related to tauopathies, including Alzheimer's disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Azure C | 65.15% | Azure C (Monomethylthionine) acts as a tau oligomer inhibitor and Aβ42 oligomerization inhibitor. Azure C regulates hsp70 ATPase activity, thereby mediating the clearance of tau protein. Azure C reduces the levels of toxic tau oligomers by promoting the formation of non-toxic tau aggregates, rescues neuroblastoma cells from tau oligomer-induced toxicity, and binds to and inhibits Aβ42 oligomerization. Azure C is generated via continuous oxidation of methylene blue or azure B through a horseradish peroxidase-mediated reaction. Azure C can be used in research related to tauopathies, including Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Lo Cascio F, et al. Azure C Targets and Modulates Toxic Tau Oligomers. ACS Chem Neurosci. 2018;9(6):1317-1326. [Content Brief]
- [2]. Viridiana S, et al. Methylene blue and azure B oxidation by horseradish peroxidase: a comparative evaluation of class II and class III peroxidases. Applied Catalysis B: Environmental. Volume 42, Issue 2, 8 May 2003, Pages 213-221.
