Leucomethylene blue mesylate
Based on 6 publication(s) in Google Scholar
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes.
For research use only. We do not sell to patients.
- Purity: 98.06%
- CAS No.: 1236208-20-0
- Formula: C18H27N3O6S3
- Molecular Weight:477.62
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Leucomethylene blue mesylate
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Customer Validation & Images
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IF
Biological Activity
Ki: 0.12 μM (tau)[3].
Leucomethylene blue (100 nM, 48 h) mesylate not only decreases the tau and p-tau expression levels, but also reverses the promoting effects of Aβ25-35 on orexin A and adenosine A1R expression levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human SH-SY5Y cell line.
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Concentration:100 nM.
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Incubation Time:48 h.
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Result:Aβ25-35 and TRx 0237 co-treatment significantly reversed the promoting effects of Aβ25-35 on tau, p-tau, orexin A and adenosine A1R expression.
Chemical Information
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CAS No. 1236208-20-0
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Appearance Solid
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Molecular Weight 477.62
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Formula C18H27N3O6S3
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Color Light green to green
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SMILES
CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1.CS(=O)(O)=O.CS(=O)(O)=O
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Synonyms
TRx0237 mesylate; Methylene blue leuco base mesylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Commun
Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology. [Abstract]2023 Sep 6;14(1):5444. PMID: 37673952 -
Adv Sci (Weinh)
Tau Aggregation-Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14-3-3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis. [Abstract]2024 Jun;11(23):e2310134. PMID: 38634567 -
Cancers (Basel)
Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma. [Abstract]2022 Sep 19;14(18):4535. PMID: 36139693 -
Bioorg Med Chem
Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. [Abstract]2018 Sep 1;26(16):4693-4705. PMID: 30107970
Leucomethylene blue mesylate purchased from MedChemExpress. Usage Cited in: Bioorg Med Chem. 2018 Sep 1;26(16):4693-4705. [Abstract]
Imaging of HEK-293T cells incubated with or without LMTM (0.5 μM) and 30 (1 μM).
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Solvent & Solubility
H2O : 83.33 mg/mL (174.47 mM; Need ultrasonic)
DMSO : 75 mg/mL (157.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Gaudette NF, et al. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine andB6C3F1 mouse urine. J Anal Toxicol. 2005 Jan-Feb;29(1):28-33. [Content Brief]
[2]. Zhenhua Liu, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. Int J Mol Med. 2019 Jan;43(1):435-442. [Content Brief]
[3]. Francesco Panza, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother. 2016;17(4):457-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.0937 mL | 10.4686 mL | 20.9371 mL | 52.3429 mL |
| 5 mM | 0.4187 mL | 2.0937 mL | 4.1874 mL | 10.4686 mL | |
| 10 mM | 0.2094 mL | 1.0469 mL | 2.0937 mL | 5.2343 mL | |
| 15 mM | 0.1396 mL | 0.6979 mL | 1.3958 mL | 3.4895 mL | |
| 20 mM | 0.1047 mL | 0.5234 mL | 1.0469 mL | 2.6171 mL | |
| 25 mM | 0.0837 mL | 0.4187 mL | 0.8375 mL | 2.0937 mL | |
| 30 mM | 0.0698 mL | 0.3490 mL | 0.6979 mL | 1.7448 mL | |
| 40 mM | 0.0523 mL | 0.2617 mL | 0.5234 mL | 1.3086 mL | |
| 50 mM | 0.0419 mL | 0.2094 mL | 0.4187 mL | 1.0469 mL | |
| 60 mM | 0.0349 mL | 0.1745 mL | 0.3490 mL | 0.8724 mL | |
| 80 mM | 0.0262 mL | 0.1309 mL | 0.2617 mL | 0.6543 mL | |
| 100 mM | 0.0209 mL | 0.1047 mL | 0.2094 mL | 0.5234 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Leucomethylene blue mesylate Related Classifications
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