1. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  2. Dengue virus TRP Channel Flavivirus
  3. SN 2

SN 2 

Cat. No.: HY-16696 Purity: 99.16%
COA Handling Instructions

SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV).

For research use only. We do not sell to patients.

SN 2 Chemical Structure

SN 2 Chemical Structure

CAS No. : 823218-99-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 100 In-stock
Solution
10 mM * 1 mL in DMSO USD 100 In-stock
Solid
5 mg USD 91 In-stock
10 mg USD 147 In-stock
50 mg USD 618 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SN 2 purchased from MedChemExpress. Usage Cited in: Gene. 2023 Feb 20;147291.

    SN-2 (5, 10, 20 μM) dose-dependently upregulates the expression of three inflammatory marker genes, IL-1β, IL-6 and TNFα in A549 cells.

    SN 2 purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2020 Oct;182:104922.  [Abstract]

    SN-2 treatment could decrease both DENV2 RNA and DENV2 E protein in a dose-dependent manner under noncytotoxic concentrations in A549 cells. SN-2 treatment also dose-dependently inhibits both ZIKV RNA and ZIKV E protein in A549 cells.

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    Description

    SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV)[2].

    IC50 & Target

    EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]

    In Vitro

    The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    255.35

    Formula

    C17H21NO

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (391.62 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9162 mL 19.5810 mL 39.1619 mL
    5 mM 0.7832 mL 3.9162 mL 7.8324 mL
    10 mM 0.3916 mL 1.9581 mL 3.9162 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    SN 2
    Cat. No.:
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