1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. SN 2

SN 2 

Cat. No.: HY-16696 Purity: 99.86%
Handling Instructions

SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV).

For research use only. We do not sell to patients.

SN 2 Chemical Structure

SN 2 Chemical Structure

CAS No. : 823218-99-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 147 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 147 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 134 In-stock
Estimated Time of Arrival: December 31
50 mg USD 562 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE SN 2

    SN 2 purchased from MCE. Usage Cited in: Antiviral Res. 2020 Oct;182:104922.

    SN-2 treatment could decrease both DENV2 RNA and DENV2 E protein in a dose-dependent manner under noncytotoxic concentrations in A549 cells. SN-2 treatment also dose-dependently inhibits both ZIKV RNA and ZIKV E protein in A549 cells.

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    Description

    SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV)[2].

    IC50 & Target

    EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]

    In Vitro

    The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    255.35

    Formula

    C₁₇H₂₁NO

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (391.62 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9162 mL 19.5810 mL 39.1619 mL
    5 mM 0.7832 mL 3.9162 mL 7.8324 mL
    10 mM 0.3916 mL 1.9581 mL 3.9162 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    SN 2
    Cat. No.:
    HY-16696
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