Adenosine A_2B receptor (A_2BR) Agonist

LUF5834 is a selective A_2B adenosine receptor (A2BR) partial agonist (EC₅₀ = 12 nM). LUF5834 is also a partial A₁/A_2A adenosine receptor agonist (lacking selectivity) with K_i values of 2.6 and 28 nM, respectively.

MRE 0094 (Sonedenoson) is a selective activator for adenosine receptor A2A, with a K_i of 490 nM. MRE 0094 exhibits anti-platelet and anti-inflammatory activities.

2-Chloro-3-deazaadenosine is agonists for adenosine receptor, with K_is of 0.3, 0.08, 25.5 and 1.9 μM, for A1, A2A, A2B, and A3 receptors, respectively.

MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC₅₀ of 10.17 (EC₅₀ of 58 pM). MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver.

Adenosine receptor agonist 2 (Compound 10) is an adenosine A_2B receptor (A_2BR) agonist with an EC₅₀ of 0.38 nM. Adenosine receptor agonist 2 significantly inhibits the accumulation of cAMP and calcium. Adenosine receptor agonist 2 can be used for cardioprotection research.