2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Bcl-B Isoform
  6. Bcl-B Antagonist

Bcl-B Antagonist

Bcl-B Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-122275
    A-371191
    		Antagonist
    A-371191 is a selective Bcl-XL antagonist with a Ki <0.5 μM, and also acts as a mitochondria-targeting agent and chemosensitizer. A-371191 restores the sensitivity of cancer cells overexpressing Bcl-XL to Cisplatin (HY-17394) and Doxorubicin (HY-15142A). A-371191 reduces tumor volume in mice with intraperitoneal tumors. A-371191 can be used in the research of acute myeloid leukemia.