406228-58-8
Chemical Structure
A-371191
- CAS No.: 406228-58-8
- Formula:C36H47N5O5S2
- Molecular Weight:693.92
IUPAC Name: (R)-N-((4-((6-(dimethylamino)-1-(phenylthio)hexan-2-yl)amino)-3-nitrophenyl)sulfonyl)-4-(8-azaspiro[4.5]decan-8-yl)benzamide
InChIKey: OYHVBZRUUWRRKB-GDLZYMKVSA-N
SMILES: O=C(NS(=O)(C1=CC=C(N[C@H](CCCCN(C)C)CSC2=CC=CC=C2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N(CC4)CCC54CCCC5)C=C3
Biological Activity: A-371191 is a selective Bcl-XL antagonist with a Ki <0.5 μM, and also acts as a mitochondria-targeting agent and chemosensitizer. A-371191 restores the sensitivity of cancer cells overexpressing Bcl-XL to Cisplatin (HY-17394) and Doxorubicin (HY-15142A). A-371191 reduces tumor volume in mice with intraperitoneal tumors. A-371191 can be used in the research of acute myeloid leukemia[1].
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A-371191 | A-371191 is a selective Bcl-XL antagonist with a Ki <0.5 μM, and also acts as a mitochondria-targeting agent and chemosensitizer. A-371191 restores the sensitivity of cancer cells overexpressing Bcl-XL to Cisplatin (HY-17394) and Doxorubicin (HY-15142A). A-371191 reduces tumor volume in mice with intraperitoneal tumors. A-371191 can be used in the research of acute myeloid leukemia. | |||||||||||||||||||||
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