Drug Metabolite Inhibitor

Rabeprazole Sulfide is a sulfide metabolite of Rabeprazole (HY-B0656). Rabeprazole Sulfide inhibits Helicobacter pylori motility. Rabeprazole Sulfide can be used for the research of Helicobacter pylori infection.

Rotenolone is a metabolite of Rotenone (HY-B1756), inhibitor of Mitochondrial complex I, and antiproliferative agent, with an IC₅₀ of 137 nM against bovine complex I. Rotenolone undergoes biotransformation via multiple cytochrome P450 isoenzymes in rainbow trout liver microsomes. Rotenolone exhibits anticancer activity against ovarian cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer. Rotenolone can be used in studies related to ovarian cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer.

N-Desmethyl Rilmazolam is a metabolite of Rilmazolam (HY-150334) and 450191-S (HY-U00228). N-Desmethyl Rilmazolam significantly enhances the activity of 7-ethoxycoumarin O-deethylase. N-Desmethyl Rilmazolam can be used in insomnia-related studies.

Laurencin is a cyclic ether, which can be isolated red alga L. glandulifera. Laurencin prolongs the pentobarbitone-induced sleep time through inhibition of pentobarbitone metabolism.

Bromobric acid is a derivative of bromoacrylic acid with cytostatic and antineoplastic activity that can form ionic complexes with glucosamine to achieve controlled-release oral administration