HMG-CoA Reductase (HMGCR) Degrader
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PROTAC HMGCR Degrader-1
0 ImagesCat. No.: HY-171823CAS No.: 2715104-45-1PROTAC HMGCR Degrader-1 is an orally active HMGCR PROTAC degrader with IC50 of 1.32 μM. PROTAC HMGCR Degrader-1 is a lactone prodrug of PROTAC HMGCR Degrader-2 (HY-181134). PROTAC HMGCR Degrader-1 achieves high plasma exposure of the active ingredient leading to robust HMGCR degradation and demonstrating promising cholesterol-lowering efficacy in vivo. PROTAC HMGCR Degrader-1 can be used for hyperlipidemia research.
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QH536
0 ImagesCat. No.: HY-147195CAS No.: 2754254-07-2QH536 is a degrader of HMG-CoA reductase (HMGCR) with an EC50 of 0.22 μM. QH536 induces ubiquitination and degradation of HMGCR via the ubiquitin-proteasome pathway, inhibits cholesterol biosynthesis, reduces cholesterol levels, suppresses hepatic stellate cell proliferation, and decreases the expression of fibrotic and inflammatory genes/proteins without inducing intracellular cholesterol accumulation. QH536 can be used in the research of cardiovascular diseases and non-alcoholic steatohepatitis (NASH).
