2754254-07-2
Chemical Structure
QH536
- CAS. Nr.: 2754254-07-2
- Formula:C33H49N3O3
- Molecular Weight:535.76
IUPAC Name: methyl (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate
InChIKey: UFAGXNKZKGGREZ-DAMQFFQQSA-N
SMILES: C[C@@](C1=CC2)(CC(C=NN3C(C)=O)=C3C(C)1C)[C@](CC4)([H])[C@]2([H])[C@@](CC[C@]5([H])[C@H](C)CCC(N6CCOCC6)=O)([H])[C@]45C
Biological Activity: QH536 is a degrader of HMG-CoA reductase (HMGCR) with an EC50 of 0.22 μM. QH536 induces ubiquitination and degradation of HMGCR via the ubiquitin-proteasome pathway, inhibits cholesterol biosynthesis, reduces cholesterol levels, suppresses hepatic stellate cell proliferation, and decreases the expression of fibrotic and inflammatory genes/proteins without inducing intracellular cholesterol accumulation. QH536 can be used in the research of cardiovascular diseases and non-alcoholic steatohepatitis (NASH)[1].
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QH536 | QH536 is a degrader of HMG-CoA reductase (HMGCR) with an EC50 of 0.22 μM. QH536 induces ubiquitination and degradation of HMGCR via the ubiquitin-proteasome pathway, inhibits cholesterol biosynthesis, reduces cholesterol levels, suppresses hepatic stellate cell proliferation, and decreases the expression of fibrotic and inflammatory genes/proteins without inducing intracellular cholesterol accumulation. QH536 can be used in the research of cardiovascular diseases and non-alcoholic steatohepatitis (NASH). | |||||||||||||||||||||
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