2754254-07-2
Chemical Structure
QH536
- CAS No.: 2754254-07-2
- Formula:C33H49N3O3
- Molecular Weight:535.76
IUPAC Name: (R)-4-((1R,3aS,3bS,10aR,10bS,12aR)-7-acetyl-6,6,10a,12a-tetramethyl-1,2,3,3a,3b,4,6,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl)-1-morpholinopentan-1-one
InChIKey: UFAGXNKZKGGREZ-DAMQFFQQSA-N
SMILES: C[C@@](C1=CC2)(CC(C=NN3C(C)=O)=C3C(C)1C)[C@](CC4)([H])[C@]2([H])[C@@](CC[C@]5([H])[C@H](C)CCC(N6CCOCC6)=O)([H])[C@]45C
Biological Activity: QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].
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QH536 | QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research. | |||||||||||||||||||||
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Keywords
