2. Signaling Pathways
  3. GPCR/G Protein
  4. LPL Receptor
  5. S1PR1 Isoform
  6. S1PR1 Antagonist

S1PR1 Antagonist

S1PR1 Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-158417
    KSI-6666
    		Antagonist
    KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model.
  • HY-182626
    CS1P1
    		Antagonist
    CS1P1 is a brain-penetrant and selective S1PR1 antagonist and PET radiotracer, with human S1PR1 IC50 values of 2.1 nM. CS1P1 binds specifically to S1PR1 to enable in vivo receptor expression quantification. CS1P1 can be used as PET radiotracer when labelled with 11C. CS1P1 can be used for the research of multiple sclerosis, neointimal hyperplasia, vascular inflammation.