Lactate Dehydrogenase Modulator

Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.

Parishin E is a modulator of hexokinase 2, lactate dehydrogenase A, and silent information regulator 6 (sirtuin 6), and is also a component present in Gastrodia elata Blume. Parishin E reduces the expression of hexokinase 2 and lactate dehydrogenase A, thereby regulating the process of cellular glycolysis. Parishin E regulates the deacetylation mediated by silent information regulator 6 (Sirtuin 6), and inhibits histone 3 lactylation modifications at the H3K₁₈la and H3K₂₇la sites. Parishin E inhibits macrophage polarization. Parishin E alleviates LPS-induced inflammatory responses and suppresses the expression of pro-inflammatory cytokines. Parishin E exerts ameliorating effects on rheumatoid arthritis. Parishin E can be used in studies related to rheumatoid arthritis.